Red Wings vs. Sabres Odds & Betting Predictions - October 22, 2025

Red Wings at Sabres

11:30 pm • TNT

Detroit Red Wings

36-23-8

2 - 4

Buffalo Sabres

41-20-6

MatchupOpenSpreadTotalMoneyline
Red Wings 36-23-8	+1.5	+1.5-247	o6.5+105	-102
Sabres 41-20-6	u6.5	-1.5+195	u6.5-125	-122

Wednesday 11:30 p.m.

October 22, 2025

KeyBank CenterBuffalo

BUF +120 (Live)

0.6u

To Win in Regulation (No Overtime)

Under 6.5-132

BUF -110

0.91u

DET -110

1.1u

DET +100

X: PicksOffice

BUF -110

0.91u

T.Thompson Anytime Goal Scorer Yes+145

0.5u

https://www.dailyfaceoff.com/news/nhl-player-prop-bets-oct22

B.Byram o0.5 Pts+185

0.26u

Tailing the ScoresAndOdds team

BUF -104

Red Wings vs Sabres: A Moneyline Pick for Tonight
Greg Liodice•
Oct 22, 2025 UTC

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NHL Public Betting

Sabres are 3-2 in their last 5 games.
Sabres are 3-2 in their last 5 games against the spread
Sabres are 21-12 in their road games against the spread
The totals have gone OVER in 2 of Sabres' last 5 games
The totals have gone OVER in 16 of Sabres' 34 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Sabres	39-28	18-16	21-12	14-17	24-9
Red Wings	34-33	12-20	22-13	9-21	24-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Sabres	32-35	16-18	16-17	16-15	15-18
Red Wings	31-36	15-17	16-19	11-19	18-17

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Sabres	41-20	N/A	N/A	20-11	20-13
Red Wings	36-23	N/A	N/A	16-14	18-17

date	opponent	score	spread	over/under	moneyline
Oct 20th	@MTL	L 2-4	+1.5 L	U 6.5	MTL +124
Oct 18th	FLA	W 3-0	+1.5 W	U 5.5	BUF +130
Oct 15th	OTT	W 8-4	+1.5 W	O 6.5	BUF -110
Oct 13th	COL	L 1-3	+1.5 L	U 6.5	COL +152
Oct 11th	@BOS	L 1-3	+1.5 L	U 5.5	BOS -104

Tanner Pearson
LW
Pearson is day-to-day with lower body
Day-to-Day
Mattias Samuelsson
D
Samuelsson is day-to-day with undisclosed
Day-to-Day
Jordan Greenway
LW
Greenway is out with abdomen
Out
Colten Ellis
G
Ellis is day-to-day with undisclosed
Day-to-Day
Tyson Kozak
C
Kozak is day-to-day with undisclosed
Day-to-Day
Justin Danforth
RW
Danforth is day-to-day with lower body
Day-to-Day
Jiri Kulich
C
Kulich is out for season with ear
Out for Season

Dylan Larkin
F
Larkin is out with leg
Out
Andrew Copp
C
Copp is out with leg
Out
Michael Rasmussen
C
Rasmussen is out with undisclosed
Out
Michael Brandsegg-Nygard
RW
Brandsegg-Nygard is day-to-day with undisclosed
Day-to-Day

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Red Wings

Sabres

Goals

Assists

Penalties

Shots

Hits

Faceoffs Won

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MatchupOverUnder
Red Wings 36-23-8	N/A	N/A
Sabres 41-20-6	N/A	N/A

Red Wings vs. Sabres Odds & Betting Predictions - October 22, 2025

Red Wings at Sabres

Detroit Red Wings

Buffalo Sabres

Red Wings at Sabres Odds

Spread, Total, Moneyline

Red Wings vs. Sabres Previews & Analysis

Red Wings vs Sabres: A Moneyline Pick for Tonight

Prop Odds Comparison

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Red Wings vs. Sabres Public Betting Percentages

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Public

Sabres

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Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Sabres vs. Red Wings Injury Updates

Sabres Injuries

Red Wings Injuries

Red Wings vs. Sabres Odds Comparison

Red Wings at Sabres Team Totals