Astros vs Cubs Odds: Moneyline, Over/Under, Props - May 22, 2026

Astros at Cubs

6:20 pm • Apple TV+

Houston Astros

51-54

4 - 2

Chicago Cubs

58-45

pitcher		team	era	w-l
J.Taillon			5.38	2-5
S.Arrighetti			4.60	7-5

MatchupOpenSpreadTotalMoneyline
Astros 51-54	+1.5	+1.5-186	o7+100	+124
Cubs 58-45	u7.5	-1.5+158	u7-120	-149

Friday 6:20 p.m.

May 22, 2026

Wrigley FieldChicago

Over 7+105

0.25u

Small to -105. Can target Over 6.5 or 4.5/5 live

Under 3.5 (F5)+104

1.25u

Y.Alvarez o0.5 HR+470

0.25u

@cowhitchurch ⭐️ https://myaction.app/mcSZfWMQl3b

S.Arrighetti o16.5 Outs-108

1.08u

Under 7.5-130

HOU +125

1.25u

Over 7-110

0.55u

(DK) Bucking the weather trends here because both pitchers have xERAs within 0.1 of 5.00 and SIERAs within 0.17 of 4.50. Both offenses > 110 wRC+ Hm/Rd & > 105 v RHP. Both proj. Lus > 110 v RHP since LY. Two solid defenses (CHC maybe beset), but also a pair of bottom third of the league pen estimators L30 days (HOU 2nd worst).

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No props found

MLB Public Betting

Cubs are 3-2 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 25-26 in their road games against the spread
The totals have gone OVER in 3 of Cubs' last 5 games
The totals have gone OVER in 28 of Cubs' 52 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	45-58	20-32	25-26	29-41	16-16
Astros	51-54	25-28	26-26	13-23	36-28

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	54-49	28-24	26-25	36-34	18-14
Astros	53-46-6	28-23-2	25-23-4	20-15-1	32-27-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	58-45	30-22	28-23	40-30	17-15
Astros	51-54	26-27	25-27	16-20	33-31

date	opponent	score	spread	over/under	moneyline
May 20th	MIL	L 0-5	+1.5 L	U 6.5	MIL -112
May 19th	MIL	L 2-5	+1.5 L	U 7.5	MIL +103
May 18th	MIL	L 3-9	-1.5 L	O 10.5	MIL -161
May 17th	@CWS	L 8-9	-1.5 L	O 9	CWS -131
May 16th	@CWS	L 3-8	-1.5 L	O 8.5	CWS -108

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RS.Arrighetti, P	89	5	5	0
LS.Okert, P	6	0.1	0	2
RE.De Los Santos, P	19	1.2	1	0
RB.Abreu, P	14	0.2	0	0
LB.King, P	17	1.1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Pena, SS	1-5	0	0	0
2I.Paredes, 3B	1-4	1	0	0
3Y.Alvarez, DH	1-3	0	0	0
4C.Walker, 1B	1-5	1	0	0
5J.Meyers, CF	1-4	0	0	0
6B.Shewmake, 2B	0-1	1	0	0
6B.Matthews, PH	1-2	0	0	1
6B.Matthews, 2B	1-2	0	0	1
6N.Allen, 2B	0-0	0	0	0
7C.Smith, RF	1-4	0	0	0
8Z.Cole, LF	0-4	0	0	1
9C.Vazquez, C	2-4	1	1	2

PITCHER	PC	IP	K	ER
RJ.Taillon, P	90	4.2	5	4
LH.Milner, P	8	0.1	0	0
RE.Roberts, P	32	2	2	0
RJ.Webb, P	15	1	2	0
RP.Maton, P	22	1	1	0

HITTERS	H-AB	R	HR	RBI
1N.Hoerner, 2B	0-4	0	0	0
2M.Busch, 1B	0-3	0	0	0
3A.Bregman, 3B	1-3	0	0	0
4I.Happ, LF	1-5	0	0	0
5S.Suzuki, RF	0-4	0	0	0
6M.Conforto, DH	0-2	0	0	0
6M.Amaya, PH	1-1	1	0	0
6M.Amaya, DH	1-1	1	0	0
6M.Ballesteros, PH	0-1	0	0	0
6M.Ballesteros, DH	0-1	0	0	0
7C.Kelly, C	0-3	0	0	0
8P.Crow-Armstrong, CF	1-2	1	1	2
9D.Swanson, SS	0-4	0	0	0