Astros vs. Cubs Odds & Betting Predictions - May 22, 2026

Astros at Cubs

6:20 pm • Apple TV+

Houston Astros

@

Chicago Cubs

pitcher		team	era	w-l
J.Taillon			0.00	0-0
S.Arrighetti			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Astros 19-30	N/A	N/A	N/A
Cubs 29-19	N/A	N/A	N/A

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Friday 6:20 p.m.

May 22, 2026

Wrigley FieldChicago

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59°Fahrenheit

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0%Rain

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12Wind

No props found

MLB Public Betting

Cubs are 2-3 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 9-15 in their road games against the spread
The totals have gone OVER in 4 of Cubs' last 5 games
The totals have gone OVER in 14 of Cubs' 24 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	21-27	12-12	9-15	14-17	7-10
Astros	19-30	11-15	8-15	4-11	15-18

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	28-20	14-10	14-10	17-14	11-6
Astros	27-18-4	16-9-1	11-9-3	9-6	17-12-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	29-19	18-6	11-13	21-10	8-9
Astros	19-30	12-14	7-16	5-10	14-19

date	opponent	score	spread	over/under	moneyline
May 19th	MIL	L 2-5	+1.5 L	U 7.5	MIL +103
May 18th	MIL	L 3-9	-1.5 L	O 10.5	MIL -162
May 17th	@CWS	L 8-9	-1.5 L	O 9	CWS -131
May 16th	@CWS	L 3-8	-1.5 L	O 8.5	CWS -109
May 15th	@CWS	W 10-5	-1.5 W	O 8.5	CHC -125

Lance McCullers
SP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out

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MatchupOverUnder
Astros 19-30	N/A	N/A
Cubs 29-19	N/A	N/A