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Guardians vs. Reds Odds & Betting Predictions - May 16, 2025

Guardians at Reds

9:10 pm • CLEG

Cleveland Guardians

1-2
4
4 - 5

Cincinnati Reds

0-2
5
Starting Pitchers
pitcherteameraw-l
Brady Singer logoB.SingerCincinnati Reds logo4.0314-12
Tanner Bibee logoT.BibeeCleveland Guardians logo4.2512-11

Guardians at Reds Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
1-2
-1.5
-1.5+130
o9.5+100
-122
Reds
0-2
u9
+1.5-156
u9.5-119
+102
location pinFriday 9:10 p.m.
May 16, 2025
Great American Ball ParkCincinnati
Guardians vs. Reds Expert Picks
The Degenerates
The Degenerates
Last 30d: 75-73-2 (-4.0u)
CLE -116 (Live)
1.16u
Wags Wins
Wags Wins
Last 30d: 201-199-1 (-6.8u)
Over 9.5-102
1.5u
Greg DiNardo
Greg DiNardo
Last 30d: 0-0-0 (+0.0u)
CLE -121
1.21u
Allan Lem
Allan Lem
Last 30d: 173-129-3 (+13.3u)
B.Singer u4.5 Ks+108
0.5u
This one showed up in the ScoresAndOdds model and I like it at plus odds. Cleveland ranks 20th this season in strikeout rate vs RHP (20.7%). Active roster has struck out 15.6% against Singer in their career.
Grant Neiffer
Grant Neiffer
Last 30d: 45-79-2 (+5.7u)
K.Manzardo o0.5 HR+340
0.5u
Lines at Lunch
Lines at Lunch
Last 30d: 92-101-5 (-20.0u)
Under 9-115
1.15u
Ryan Sura
Ryan Sura
Last 30d: 62-79-0 (-21.3u)
Under 9-115
1.15u
Matt DiLeo
Matt DiLeo
Last 30d: 56-43-1 (+3.4u)
CLE o1.5 Team Total (F5)-155
0.65u
CLE o2.5 Team Total (F5)+125
0.31u
Billy Ward
Billy Ward
Last 30d: 10-19-0 (-3.8u)
Over 0.5 (1st Inn)+100
1.05u
Brandon Kravitz
Brandon Kravitz
Last 30d: 83-93-2 (-4.8u)
Under 8.5+105
1u
Cam Is Money
Cam Is Money
Last 30d: 118-108-2 (+8.1u)
CLE -118 (F5)
1.18u
Sean Zerillo
Sean Zerillo
Last 30d: 53-86-0 (-3.2u)
Over 9-105
0.53u
Bet to -115

Guardians vs. Reds Previews & Analysis

  • 3 MLB NRFI & YRFI Picks for Friday article feature image

    3 MLB NRFI & YRFI Picks for Friday

    Billy Ward•
    May 16, 2025 UTC
  • Guardians vs. Reds: 2 HR Bets for Friday article feature image

    Guardians vs. Reds: 2 HR Bets for Friday

    Grant Neiffer•
    May 16, 2025 UTC
See more MLB Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Reds Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Reds

67%

Bets%

33%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Reds are 3-2 in their last 5 games.
  • Reds are 2-3 in their last 5 games against the spread
  • Reds are 42-39 in their road games against the spread
  • The totals have gone OVER in 1 of Reds' last 5 games
  • The totals have gone OVER in 26 of Reds' 79 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Reds		82-7840-3942-3929-4353-34
Guardians		86-7639-4247-3433-3651-38

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Reds		58-91-1126-45-832-46-320-47-537-44-6
Guardians		69-87-637-41-332-46-334-34-134-50-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Reds		83-7944-3538-4339-3343-44
Guardians		88-7445-3643-3844-2543-46

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 15thCWSW 7-1-1.5 WU 9CIN -245
May 14thCWSL 2-4-1.5 LU 8.5CWS -197
May 13thCWSL 1-5-1.5 LU 9CWS -210
May 11th@HOUL 0-6+1.5 LU 8.5HOU +124
May 10th@HOUW 13-9+1.5 WO 8CIN +105

Guardians vs. Reds Injury Updates

Guardians Injuries

    Reds Injuries

    • Keegan Thompson
      RP

      Thompson is out with inactive

      Out

    • Noelvi Marte
      3B

      Marte is day-to-day with side

      Day-to-Day

    • Brandon Williamson
      SP

      Williamson is out for season with elbow

      Out for Season

    • Graham Ashcraft
      RP

      Ashcraft is out with groin

      Out

    • Chase Burns
      SP

      Burns is out with hip

      Out

    • Julian Aguiar
      SP

      Aguiar is out for season with elbow

      Out for Season

    • Rhett Lowder
      SP

      Lowder is out with elbow

      Out

    • Carson Spiers
      RP

      Spiers is out with shoulder

      Out

    See more MLB Injuries Right Arrow
    Guardians vs. Reds Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Tanner Bibee logoRT.Bibee, P105644
    Matt Festa logoRM.Festa, P28230
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF0-3100
    Nolan Jones logo2N.Jones, CF0-4000
    Jose Ramirez logo3J.Ramirez, 3B1-4111
    Kyle Manzardo logo4K.Manzardo, DH1-4100
    Carlos Santana logo5C.Santana, 1B1-4002
    Daniel Schneemann logo6D.Schneemann, 2B1-3000
    Gabriel Arias logo7G.Arias, SS0-2000
    Bo Naylor logo8B.Naylor, C1-3111
    Will Brennan logo9W.Brennan, RF0-3000
    Reds Player Stats
    Projected
    PITCHERPCIPKER
    Brady Singer logoRB.Singer, P90543
    Taylor Rogers logoLT.Rogers, P12100
    Graham Ashcraft logoRG.Ashcraft, P5100
    Tony Santillan logoRT.Santillan, P11101
    Emilio Pagan logoRE.Pagan, P16110
    HITTERSH-ABRHRRBI
    TJ Friedl logo1T.Friedl, CF0-3000
    Santiago Espinal logo2S.Espinal, 3B1-4000
    Elly De La Cruz logo3E.De La Cruz, SS1-3000
    Austin Hays logo4A.Hays, LF2-4111
    Gavin Lux logo5G.Lux, DH2-4100
    Spencer Steer logo6S.Steer, 1B1-4100
    Tyler Stephenson logo7T.Stephenson, C1-4000
    Will Benson logo8W.Benson, RF2-4113
    Matt McLain logo9M.McLain, 2B1-4100

    Guardians vs. Reds Odds Comparison

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    Guardians at Reds Team Totals

    MatchupOverUnder
    Guardians
    1-2
    o4.5-125
    u4.5-105
    Reds
    0-2
    o4.5+105
    u4.5-135