Twins vs. Giants Odds & Betting Predictions - September 22, 2026

Twins at Giants

1:45 am • NBCS-BA
2 - 5
Starting Pitchers
pitcherteameraw-l
Blade Tidwell logoB.TidwellSan Francisco Giants logo4.451-2
Zebby Matthews logoZ.MatthewsMinnesota Twins logo4.909-11

Twins at Giants Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
0-0
-1.5
-1.5+134
o8-109
-133
Giants
0-0
u8
+1.5-157
u8-110
+110
location pinTuesday 1:45 a.m.
September 22, 2026
Oracle ParkSan Francisco
Twins vs. Giants Expert Picks
Kyle Murray
Kyle Murray
Last 30d: 136-150-7 (+0.5u)
Z.Matthews o4.5 Ks-105
1u
Adam Kaufman
Adam Kaufman
Last 30d: 333-306-16 (-16.4u)
MIN -115
1.15u
Scott Rickenbach
Scott Rickenbach
Last 30d: 99-90-2 (-1.2u)
Over 4.5 (F5)-120
0.83u
Charlie DiSturco
Charlie DiSturco
Last 30d: 118-237-2 (-3.1u)
Z.Matthews o4.5 Ks-108
0.5u
Z.Matthews To Record 6+ Strikeouts Yes+196
0.49u
tonysartori99
Last 30d: 13-12-0 (+3.5u)
Over 8-118
1u

Twins vs. Giants Previews & Analysis

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    Largest Prop Edge for Twins vs Giants

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  • Twins vs Giants: A Clear Spot to Attack article feature image

    Twins vs Giants: A Clear Spot to Attack

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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Giants Public Betting Percentages

Away Logo

Twins

Public

75%

Bets%

25%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Giants
80-8241-4039-4221-2758-54
Twins
82-8040-4142-3924-3456-45

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Giants
75-77-1036-42-339-35-727-18-347-58-7
Twins
88-67-741-36-447-31-327-30-159-36-6

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Giants
65-9737-4428-5324-2440-72
Twins
77-8542-3935-4631-2744-57

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20th@LADL 1-3+1.5 LU 8.5LAD +227
Sep 20th@LADL 4-10+1.5 LO 7.5LAD +334
Sep 19th@LADL 2-8+1.5 LO 8.5LAD +257
Sep 16th@STLW 6-5+1.5 WO 8.5SF +140
Sep 15th@STLW 10-3+1.5 WO 8.5SF +153

Twins vs. Giants Injury Updates

Twins Injuries

  • Pablo Lopez
    SP

    Lopez is out with elbow

    Out

  • David Festa
    SP

    Festa is out with shoulder

    Out

  • Travis Adams
    SP

    Adams is out with triceps

    Out

Giants Injuries

  • Hayden Birdsong
    SP

    Birdsong is out with arm

    Out

Twins vs. Giants Box Score
Twins Player Stats
Projected
PITCHERPCIPKER
Zebby Matthews logoRZ.Matthews, P100595
Taylor Rogers logoLT.Rogers, P251.110
Travis Adams logoRT.Adams, P201.230
HITTERSH-ABRHRRBI
Walker Jenkins logo1W.Jenkins, CF1-4000
Luke Keaschall logo2L.Keaschall, RF0-4000
Brooks Lee logo3B.Lee, 3B1-4111
Kody Clemens logo4K.Clemens, 2B0-4000
Ryan Jeffers logo5R.Jeffers, C0-4000
Alan Roden logo6A.Roden, DH1-2000
Aaron Sabato logo7A.Sabato, 1B0-3000
Emmanuel Rodriguez logo8E.Rodriguez, LF1-3111
Ryan Kreidler logo9R.Kreidler, SS0-3000
Giants Player Stats
Projected
PITCHERPCIPKER
Blade Tidwell logoRB.Tidwell, P573.141
Tristan Beck logoRT.Beck, P322.210
Sam Hentges logoLS.Hentges, P20120
Jason Foley logoRJ.Foley, P9101
Trent Harris logoRT.Harris, P16110
HITTERSH-ABRHRRBI
Drew Gilbert logo1D.Gilbert, CF3-4213
Jonah Cox logo2J.Cox, 2B1-4000
Bo Davidson logo3B.Davidson, RF1-4100
Marcelo Mayer logo4M.Mayer, DH0-4000
Brett Harris logo5B.Harris, 1B2-4002
Drew Cavanaugh logo6D.Cavanaugh, C0-2000
Andrew Knizner logo6A.Knizner, PH1-2000
Andrew Knizner logo6A.Knizner, C1-2000
Osleivis Basabe logo7O.Basabe, 3B1-3100
Shay Whitcomb logo7S.Whitcomb, 3B0-0000
Scott Bandura logo8S.Bandura, LF0-3000
Turner Hill logo8T.Hill, LF0-0000
Christian Koss logo9C.Koss, SS1-3100

Twins vs. Giants Odds Comparison

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Twins at Giants Team Totals

MatchupOverUnder
Twins
0-0
N/A
N/A
Giants
0-0
N/A
N/A