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Cubs vs Diamondbacks Prediction, Pick, MLB Odds for Tuesday, August 25

Cubs vs Diamondbacks Prediction, Pick, MLB Odds for Tuesday, August 25 article feature image
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Aug 19, 2026; Boston, Massachusetts, USA; Arizona Diamondbacks starting pitcher Brandon Pfaadt (32) pitches against the Boston Red Sox during the first inning at Fenway Park. Mandatory Credit: Brian Fluharty-Imagn Images

The Arizona Diamondbacks host the Chicago Cubs on August 25, 2026. First pitch from Chase Field is scheduled for 9:40 p.m. EDT. The game will be broadcast on MARQ.

Find my MLB picks and Cubs vs Diamondbacks prediction below.


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Cubs vs Diamondbacks Prediction

  • Cubs vs Diamondbacks Pick: Under 8.5 (54c, Kalshi)

Cubs vs Diamondbacks Odds


Cubs vs Diamondbacks Probable Pitchers

Clay Holmes (RHP, CHC)StatBrandon Pfaadt (RHP, ARI)
5-6W-L7-1
1.4fWAR (FanGraphs)1.3
2.49 / 4.05ERA / xERA3.39 / 3.56
3.43 / 3.76FIP / xFIP3.99 / 4.24
9.7%K-BB%11.2%
59.9%GB%48.0%
.245BABIP.261
99Stuff+95
100Location+104

Cubs vs Diamondbacks MLB Preview

Our own Sean Zerillo projects some value on the Under in this game.

Per BARTOLO, our new PRO baseball betting tool, Zerillo projects just 7.7 runs for this matchup.

Opening Pitch: Find Tuesday's Best Bets Using BARTOLO Image

These are two underrated starting pitchers. Clay Holmes has been lights out over his past two starts (one earned run across 12 innings). Brandon Pfaadt has a 1.79 ERA since returning from injury at the end of June — including his most recent start against Boston, where he allowed five earned runs despite eight strikeouts and no walks.

While these two bullpens are around league-average (the Cubs are below-average, while the Diamondbacks are above-average), both are fully rested entering this matchup.

If you'd like access to all this information and more, I reccomend getting an Action PRO subscription and checking out BARTOLO today.

Pick: Under 8.5 (54c, Kalshi)

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About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

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