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Cubs vs Mariners Prediction, Pick, MLB Odds for Saturday, August 22

Cubs vs Mariners Prediction, Pick, MLB Odds for Saturday, August 22 article feature image
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Michael McLoone and Jayne Kamin-Oncea-Imagn Images. Pictured: Cubs SP David Peterson, Mariners SP Kade Anderson

The Seattle Mariners host the Chicago Cubs on August 22, 2026. First pitch from T-Mobile Park is scheduled for 7:15 p.m. ET. The game will be broadcast on FOX.

The Mariners are favored by -112 on the moneyline and are +1.5 on the run line. The Cubs are +104 on the moneyline and -1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Cubs vs Mariners prediction below, as well as probable pitchers, weather report, and more.


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Cubs vs Mariners Prediction

  • Cubs vs Mariners Pick: Mariners ML (-112)

My Cubs vs Mariners best bet is on Seattle to win outright. Make sure to find the best odds by checking our live MLB odds page.


Cubs vs Mariners Odds

Cubs Logo
Saturday, Aug 22
7:15 p.m. ET
FOX
Mariners Logo
Cubs Odds
SpreadTotalMoneyline
-1.5
+167
7.5
-106o / -113u
+104
Mariners Odds
SpreadTotalMoneyline
+1.5
-204
7.5
-106o / -113u
-112
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Cubs vs Mariners moneyline: Cubs +104, Mariners -112
  • Cubs vs Mariners over/under: 7.5 (-106o / -113u)
  • Cubs vs Mariners spread: Cubs -1.5 (+167), Mariners +1.5 (-204)

Cubs vs Mariners Probable Pitchers

David Peterson (LHP, CHC)StatKade Anderson (LHP, SEA -AA-)
7-7W-L10-1
1.2fWAR (FanGraphs)N/A
5.29 / 4.97ERA / xERA1.06 / N/A
4.00 / 4.14FIP / xFIP1.78 / 2.59
9.5K-BB%36.6
49.3GB%45.3
.325BABIP.239
89Stuff+N/A
101Location+N/A

Cubs vs Mariners MLB Betting Preview

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Chicago Cubs Betting Preview

The Cubs (74-55) blew an early 3-0 lead in their loss in the series opener against the Mariners on Friday. Chicago has now lost four of its last six games.

They're sending out David Peterson to the mound today. The veteran lefty made a one-inning appearance on August 17th in an extra-inning game. Previously, he was being deployed as a regular starter.

This disruption in routine could negatively affect his performance today.

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Seattle Mariners Betting Preview

The Mariners (61-68) got a much-needed win in extra innings on Friday. Their playoff hopes are hanging by a thread, as they're currently three games back of the final AL Wild Card spot.

Tonight is an exciting game for Mariners fans. After a long wait, Kade Anderson is finally making his big-league debut.

This is the undisputed best pitching prospect in baseball. He's put up video game numbers in Double-A this season after coming into the year with high expectations.

There's a good chance he gets to dominate immediately.


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Cubs vs Mariners Pick, Betting Analysis

I'm going with the Mariners moneyline here.

I'm betting Seattle bats can get to Peterson, who has a 5.29 ERA and a 1.53 WHIP on the season, fresh off a one-inning appearance, which could disrupt his routine and produce negative results for this outing.

But more importantly, this is a bet on Kade Anderson. He's been absolutely dominant this season, putting up an absurd 36.6 strikeout-to-walk percentage and a 2.59 xFIP at Double-A.

Anderson was touted as a polished prospect coming out of college, and he's proven that this season.

Look for at least five dominant innings from Anderson here, which should be enough to give the Mariners the edge in this matchup.

We're getting a cheap price on the home team, making it even more appealing.

Pick: Mariners ML (-112, DraftKings)


Cubs vs Mariners Weather


Get the latest coverage on MLB Weather.


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About the Author
Frank AmmiranteVerified Action Expert

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