The Pittsburgh Pirates host the Milwaukee Brewers on September 6, 2025. First pitch from PNC Park is scheduled for 6:40 p.m. EDT; the game will be broadcast on FDSWI.
Find my MLB betting preview and Brewers vs Pirates prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Brewers vs Pirates Prediction
- Brewers vs Pirates pick: Brandon Woodruff Over 5.5 Strikeouts (-140)
My Brewers vs Pirates best bet is Over 5.5 strikeouts for the Brewers' Brandon Woodruff today. Make sure to find the best odds by checking our live MLB odds page.
Brewers vs Pirates Odds
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +115 | 7.5 -120o / 100u | -145 |
| Pirates Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -140 | 7.5 -120o / 100u | +120 |
Brewers vs Pirates Projected Starting Pitchers
Alex Kolodziej’s Brewers vs Pirates Preview, Prediction, Betting Analysis
A strong option for Saturday night’s Brewers-Pirates game is Brandon Woodruff hitting over 5.5 strikeouts.
Using PRO Projections, a proprietary system that analyzes betting odds, player data, and probabilities, Woodruff stands out as the top strikeout bet among pitcher props for the entire September 6 slate. The model forecasts an average of 6.4 strikeouts for the veteran starter in this matchup, offering a clear advantage over the betting line.
While Woodruff managed only three strikeouts in his most recent outing, his previous performances have been more impressive, recording six or more strikeouts in seven of his previous nine starts. Additionally, the Pirates’ lineup ranks 22nd in the league for team strikeouts, indicating a vulnerable offense that tends to strike out frequently.
Pick: Brandon Woodruff Over 5.5 Strikeouts (-140, Fanatics)
Brewers vs Pirates Betting Trends
