We still have six evening games on the Memorial Day slate, including Nationals vs Reds at 6:10 PM at Great American Ballpark on MLB.TV, Rockies vs Dodgers at 9:10 PM ET at Dodger Stadium on MLB.TV, and Mariners vs Athletics at 9:40 PM ET at Sutter Health Park on MLB.TV.
Our experts have analyzed the matchups and found great options for Memorial Day's evening slate.
Below are 4 expert MLB best bets for Memorial Day.
MLB Best Bets Today
The team logos in the table below represent each matchup our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 6:10 PM | |
  | 7:07 PM | |
  | 9:10 PM | |
  | 9:40 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Tanner McGrath's Nationals vs Guardians Prediction
Action PRO projects Washington Nationals starter Zack Littell for 2.32 strikeouts in his matchup against the Cleveland Guardians tonight, giving us a solid edge against the market when compared to his current prop line of over/under 2.5 strikeouts, which is good enough to tag the Under with a B+ grade in our system.
Littell has recorded just 23 strikeouts through his first 10 starts of the season, totaling 46.1 innings pitched. His strikeout rate sits at a modest 4.5 K/9 early in the year, with recent outings showing low totals like three Ks over five innings against the Mets and just two against the Orioles.
Tonight, Littell will face a Cleveland Guardians lineup that has posted one of the lower strikeout rates in the majors so far this season, currently sitting around 19.8% (ranking near the bottom of MLB in K%). The Guardians emphasize contact, plate discipline, and putting the ball in play, with strong fundamentals that limit swing-and-miss opportunities for opposing starters.
Littell, a veteran right-hander who relies more on command and inducing weak contact than overpowering stuff, isn’t generating high whiff volume this season. His arsenal plays better for limiting damage than racking up strikeouts, especially over multiple innings against a patient, low-K group like Cleveland’s.
Projections see him likely exiting around the 5-inning mark without the volume needed to clear 2.5 strikeouts.
Pick: Zack Littell Under 2.5 Strikeouts (+100 or Better)
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Evan Abrams's Marlins vs Blue Jays Best Bet
By Evan Abrams
Monday's Marlins vs. Blue Jays game fits a historically profitable betting system called "Bet Teams vs. Marlins After Playing on East Coast" from our Bet Labs database.
When the Marlins open a series against a team coming off a game in the Eastern or Central time zone, the market often underrates them due to the perception of minimal travel impact.
In reality, these teams enter Game 1 of the series with their routines intact and without the challenges of cross-country adjustments, allowing them to perform at expected or elevated levels.
Because the Marlins typically aren't priced as a top-tier opponent, this creates value in fading them in the series opener.
This system capitalizes on that edge by betting against the Marlins in Game 1 during the regular or postseason when their opponent's previous game was played in the Eastern or Central time zone, turning overlooked market assumptions into a profitable opportunity.
This system boasts an all-time record of 515-360, good for a win percentage of 59% an an ROI of 9%. In 2026 alone, it holds a 9-4 record (69%) and an ROI of 40%.
Blue Jays starting pitcher Trey Yesavage has been one of the best hurlers in baseball this season.
The former East Carolina Pirate has made five starts this season, pitching to a 1.07 ERA with 29 strikeouts in 25 1/3 innings.
That incredibly low ERA mark is legitimate, too. Yesavage boasts an xERA of 1.79, which ranks in the 98th percentile of all pitchers. His xBAA of .157 (99th percentile) shows how dominant he's been against opposing batters in his five starts.
We'll take Yesavage against a Marlins team that's averaging just 3.33 runs per game over its last three contests.
Pick: Blue Jays ML (-200 or Better)
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Jon Anderson's Rockies vs Dodgers Prediction
By Jon Anderson
The splits on Emmet Sheehan are pretty wild to see this year. He has a 3.76 ERA at home with a 33% strikeout rate.
On the road, it's an ERA of 6.52 with an 18% strikeout rate. That doesn't make much sense to me, and I think it's mostly random.
But there might be something going on there. What’s certain is that this will be his softest matchup of the year.
The Dodgers host the Rockies, who have had some really, really awful offensive numbers away from Coors Field the last couple of seasons.
Sheehan is ready to feast in this one.
Pick: Emmet Sheehan Over 6.5 Ks | Emmet Sheehan Over 17.5 Outs
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Kenny Ducey's Mariners vs Athletics Prediction
By Kenny Ducey
This is where the fun begins for Aaron Civale.
The Mariners not only play in a brutal park for home runs, but also hold the ninth-highest fly ball rate in the league. They sit 10th and 11th in xBA and xSLG on fly balls, respectively, and against fly-ball pitchers, they own the ninth-worst OPS in the league.
Now, some of that could be some bad luck. After all, the Mariners' expected slugging is around 1o0 points higher than their actual mark, but that's what comes with hitting so many fly balls in a bad park for that kind of approach.
Civale is an expert at securing flyouts, and he'll draw a team with a weak .153 Isolated Power over the last two weeks, which is hitting just .212 in that span.
The Athletics have been experiencing an even greater power outage, but they're hitting .247 with a low 20.8% strikeout rate in the same time.
A sustained level of contact and traffic on the basepaths should beat out a swing-for-the-fences approach, particularly considering the man on the mound for the Athletics will be licking his chops at a team that looks to elevate.
Pick: Athletics ML (-110 or Better)
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