We have a 15-game slate today, starting early with Blue Jays vs Rays at 1:10 p.m. ET and closing with Pirates vs. Diamondbacks at 9:40 p.m. ET.
Our experts have analyzed the matchups and found great options for Wednesday.
Below are five expert MLB picks and predictions for today's slate of games.
MLB Best Bets Today
The team logos in the table below represent the matchups our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:10 PM | |
  | 4:10 PM | |
  | 7:40 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Sean Paul's Blue Jays vs Rays Best Bet
By Sean Paul
I talked about the issues with the Blue Jays' lineup, so fair is fair — the Rays have been even worse over their past 14 games, ranking 24th with a 92 wRC+.
Here's what makes this Rays lineup so interesting. They have three big hitters in Junior Caminero, Yandy Diaz, and Jonathan Aranda, who each have a 130 wRC+ or better in that span. The rest of the lineup is contact hitters with speed who'll look to steal and get in scoring position for the big three.
The key? Chandler Simpson. He has zero power, but he's the fastest player in the league. It's hard for him to use his speed when he's hitting just .240, as he has in his last 14 games. The Rays have another gear to tap into when Simpson is getting on base because his speed can turn a single into a triple in two pitches.
I don't get the line here. The Rays are unequivocally a better team than Toronto, with their best pitcher on the mound against one of the worst pitchers in the league over the past five seasons. That tells me the oddsmakers don't buy this Rays' hot run, but I do. Give me Tampa Bay up to -165.
Pick: Rays ML (-150 or Better)
Read Paul's full Rays-Jays preview here:
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Alex Hinton's Braves vs Mariners Pick
By Alex Hinton
While the Mariners secured a 5-4 victory on Monday, last night's Braves' victory was a pitchers' duel. That means these teams are 1-1 to the over in this series and 3-2 over the last five meetings.
The Braves are also 4-1 to the over on their current road trip. They are averaging 5.7 runs per game and are not the most forgiving lineup that a struggling pitcher like Woo will want to face right now.
Seattle's offense may lag behind Atlanta's right now, but Martin Perez has its warts. The Mariners' offense has also been better at home this season. They have the third-most home runs at home this season, as well as a team OPS. That is nearly 100 points higher when playing at home.
With the total at eight today, there is some value on the Over. If the Braves hit Bryan Woo early, they may clear this number themselves.
Pick: Over 8 (-120 or Better)
Check out Hinton's full Braves-Mariners preview here:
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Tanner McGrath's Guardians vs Royals MLB System Bet
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
This system targets unders in regular-season MLB games where softer home starting pitchers — low strikeout rates and moderate WHIPs — are on the mound in games three or four of a series.
By this point in the series, hitters have seen multiple arms, and scouting reports are sharper, yet scoring remains muted when the matchup lacks overpowering velocity and the wind remains neutral.
The setup avoids overly run-heavy environments by filtering out strong directional wind, keeping offensive surges in check.
With the home team in the middle of the season grind, winning at a modest clip, the market may overlook how often these quiet conditions lead to slower-paced, low-scoring outcomes.
It's worth noting that our own Sean Zerillo is on this Under, projecting a total of just 6.8 runs.
Pick: Under 8 (-120 or Better)
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
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