The Baltimore Orioles host the Pittsburgh Pirates on September 10, 2025. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. EDT; the game will be broadcast on MASN.
Find my MLB betting preview and Pirates vs Orioles prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Pirates vs Orioles Prediction
- Pirates vs Orioles pick: Under 7.5
My Pirates vs Orioles best bet is on the under total runs. Make sure to find the best odds by checking our live MLB odds page.
Pirates vs Orioles Odds
| Pirates Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +120 | 7.5 100o / -120u | -155 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -145 | 7.5 100o / -120u | +130 |
Pirates vs Orioles Projected Starting Pitchers
| RHP Paul Skenes (PIT) | Stat | RHP Tyler Wells (BAL) |
|---|---|---|
| 10-9 | W-L1 | 1-0 |
| 5.8 | fWAR (FanGraphs) | 0.1 |
| 1.98/2.57 | ERA /xERA | 3.60/2.76 |
| 2.42/3.08 | FIP / xFIP | 4.14/4.61 |
| 0.94 | WHIP | 1.00 |
| 23.1% | K-BB% | 20.0% |
| 44.3% | GB% | 37.5% |
| 107 | Stuff+ | 96 |
| 112 | Location+ | 109 |
Pirates vs Orioles Prediction, Betting Analysis
The Pittsburgh Pirates enter Game 2 of their series against the Baltimore Orioles as -155 moneyline favorites, while Baltimore sits at +130 to score another upset. Oddsmakers have set the total at 7.5 runs.
The Orioles took Game 1 in dramatic fashion, 3-2, on Tuesday night. Samuel Basallo delivered an RBI single in the 11th inning—initially ruled foul—that stood as the walk-off winner.
On the mound Wednesday, the Pirates turn to Paul Skenes, who has been nearly unhittable since the All-Star break. The right-hander owns a 6-1 record with a sparkling 1.90 ERA and 0.96 WHIP across nine starts.
Baltimore counters with Tyler Wells, who has quietly excelled against Pittsburgh. Wells is 1-0 with a 2.19 ERA and 11 strikeouts over 12 1/3 innings in two outings versus the Pirates.
Beyond the pitching matchup, there’s another reason to expect a low-scoring affair: the “Wind Blowing In, Short and Long Term” system highlighted by Evan Abrams. At wind-sensitive ballparks like Camden Yards, when the wind is blowing in, run production is historically suppressed due to reduced carry on fly balls. This angle has been profitable in both the short and long term, regardless of season context.
Pick: Under 7.5 (-120, Fanatics)
Pirates vs Orioles Betting Trends
