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Giants vs Red Sox Prediction, Pick, MLB Odds for Friday, August 21

Giants vs Red Sox Prediction, Pick, MLB Odds for Friday, August 21 article feature image
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Photo Credit: Dennis Lee-Imagn Images
Pictured: Sonny Gray walks back into the dugout

The Boston Red Sox host the San Francisco Giants on August 21, 2026. First pitch from Fenway Park is scheduled for 7:10 p.m. EDT. The game will be broadcast on NESN.

The Red Sox are favored by -170 on the moneyline and by -1.5 on the run line. The Giants are +158 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Giants vs Red Sox prediction below, as well as probable pitchers, weather report, and more.


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Giants vs Red Sox Prediction

  • Giants vs Red Sox Pick: Sonny Gray Under 18.5 Outs (-246 or Better)

My Giants vs Red Sox best bet is on Gray to record under 18.5 outs. Make sure to find the best odds by checking our live MLB odds page.


Giants vs Red Sox Odds

Giants Logo
Friday, Aug 21
7:10 p.m. ET
NESN
Red Sox Logo
Giants Odds
SpreadTotalMoneyline
+1.5
-152
7.5
-101o / -119u
+158
Red Sox Odds
SpreadTotalMoneyline
-1.5
+126
7.5
-101o / -119u
-170
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Giants vs Red Sox moneyline: Giants +158, Red Sox -170
  • Giants vs Red Sox over/under: 7.5 (-101o / -119u)
  • Giants vs Red Sox spread: Red Sox -1.5 (+126), Giants +1.5 (-152)

Giants vs Red Sox Probable Pitchers

Logan WebbStatSonny Gray
8-7W-L15-3
3.1fWAR (FanGraphs)2.6
3.50 / 3.63ERA / xERA2.65 / 3.59
3.17 / 3.68FIP / xFIP3.48 / 3.61
13.9K-BB%15.5
51GB%47.2
.266BABIP.286
99Stuff+101
106Location+98

Giants vs Red Sox MLB Betting Preview

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Giants vs Red Sox Pick, Betting Analysis

Editor’s note: This article was transcribed from the latest episode of the Payoff Pitch Podcast.

By Derek Carty

I'm fading Sonny Gray in his pitcher outs prop. Under 18.5 outs at -147 at DraftKings is the best line on the board. I like it down past -200. THE BAT X is only projecting about 16.5 outs here for Gray.

I'd imagine we're getting an 18.5 line on him because he's facing the Giants, but he's a guy who is not really allowed to go super deep into games very often, especially in terms of his pitch count. He's usually like an 85-to-90-pitch guy. Occasionally, he'll be able to go over 90, you know, maybe approach 100.

The odds that we're getting imply he'd need to have a 40% chance to break even. So we're being offered value right off the bat based on that, before you even consider the projection. And the projection says that, you know, he probably should not be going as deep as he has been anyway.

So despite facing the Giants, maybe he'll be really efficient. Maybe he'll do really well because of that. But they are getting a huge park upgrade going from Oracle to Fenway, and we're getting the good side of the key number here.

So I will take this one on Gray.

Pick: Sonny Gray Under 18.5 Outs (-246 or Better)


Giants vs Red Sox Weather


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