The Minnesota Twins host the Seattle Mariners on Wednesday, June 25, 2025. First pitch from Target Field is scheduled for 7:40 p.m. ET; the game will be broadcast on ROOT Sports NW and MLB.TV.
Find my Mariners vs Twins prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
The Twins enter as -130 favorites on the moneyline, while the Mariners are +110 to pull off the upset. Meanwhile, the over/under sits at 7.5.
Mariners vs Twins Prediction
- Mariners vs. Twins Pick: Julio Rodriguez Over 0.5 Home Runs (+700)
My Twins vs. Mariners best bet is on Seattle's Julio Rodriguez to hit a home run. Make sure to find the best odds by checking our live MLB odds page.
Mariners vs Twins Odds
| Mariners Odds | ||
|---|---|---|
| Run Line | Over/Under | Moneyline |
+1.5 -205 | 7.5 -110o / -110u | +110 |
| Twins Odds | ||
|---|---|---|
| Run Line | Over/Under | Moneyline |
-1.5 +170 | 7.5 -110o / -110u | -130 |
Mariners vs Twins Projected Starting Pitchers
Mariners vs Twins MLB Betting Preview
For Wednesday’s Minnesota Twins and Seattle Mariners game, I locked in Julio Rodriguez to hit a home run.
Our PRO Projections — which leverage player performance, odds and matchup factors — forecast Rodriguez for 0.19 homers tonight. When converting this projection into a betting line, the fair value stands near +425.
However, current market prices show Rodriguez’s shortest odds at around +540, while some sportsbooks, like bet365, offer more generous odds around +700. This represents a significant betting edge worth capitalizing on, according to premium data.
Rodriguez bats in the upper third of the Mariners’ lineup, giving him plenty of opportunities to make an impact.
Mariners vs Twins Pick, Betting Analysis
Additionally, the ballpark factor plays a key role here. Target Field, where the game is being played, ranks among the top 10 most homer-friendly stadiums in MLB for right-handed hitters this season — substantially better than Rodriguez’s usual home park, T-Mobile Park, which sits in the back half of baseball for homers.
Notably, Rodriguez already demonstrated his power at Target Field just two days ago by hitting a home run. Considering these factors, a nifty price grab at +700 odds offers excellent value.
Pick: Julio Rodriguez Over 0.5 Home Runs (+700)
