2021 NCAA Tournament Biggest Bets: Six-Figure Wagers Coming in on Futures & Sweet 16 Spreads

2021 NCAA Tournament Biggest Bets: Six-Figure Wagers Coming in on Futures & Sweet 16 Spreads article feature image
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Photo by Gregory Shamus/Getty Images. Pictured: Head coach Juwan Howard of the Michigan Wolverines celebrates

Biggest Bets Heading into Sweet 16

Team Bet Win
Houston Title $1M $9M
Michigan Title $60K $465K
Alabama -6 vs. UCLA $451K $410K
Oregon +3 vs. USC $367,200 $306K
Oregon State Title $400 $300,400
Loyola-Chicago -6 vs. Oregon St $306K $255K
Florida State Title $4900 $249,900
Florida State Title $9500 $247K
Creighton Title $10K $200K
Houston Title $7K $210K
Florida State +3 vs. Michigan $222,200 $202K
USC Title $1K $200K
Loyola-Chicago Title $1K $200K

As the NCAA Tournament picture becomes clearer and fewer games remain, bigger bets are coming in to sportsbooks.

The biggest, of course, is courtesy of Mattress Mack on the Houston Cougars. The Houston business owner placed $1 million on Houston to win it all at 9-1 odds at DraftKings after flying from Houston to Denver to find the legal book.

That’s the only publicly-known bet over $500,000, but six-figure wagers are starting to roll in.

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Many of the biggest bets are on Sweet 16 spreads.

BetMGM has taken five notable six-figure bets on Sweet 16 sides, including $451K on Alabama -6 to win $410K. The Crimson Tide plays UCLA on Sunday.

There’s a $367,200 bet on Oregon +3 against USC to win $306K and another $306K bet on Loyola-Chicago -6 to win $255K. The Ramblers take on Oregon State on Saturday afternoon.

The bet with the biggest return-on-investment (ROI) opportunity is riding on the Oregon State Beavers. A bettor in Nevada placed $400 at William Hill on the Pac-12 team to win it all at the start of the NCAA Tournament at 750-1 odds. That ticket would pay out $300,400.

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