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2021 NCAA Tournament Odds: Spreads, Over/Unders For Every First-Round Game

2021 NCAA Tournament Odds: Spreads, Over/Unders For Every First-Round Game article feature image
Credit:

Michael Hickey/Getty Images. Pictured: Ayo Dosunmu.

  • 2021 NCAA Tournament odds are out, complete with spreads and totals from sportsbooks.
  • We've outlined every spread, over/under and moneyline below for the First Four games, and every other first-round matchup that's set.

Let the madness begin!

Find NCAA Tournament odds for every First Four and Round of 64 matchup outlined below.

Note that lines are as of 8 p.m. ET and via PointsBet, where you can bet $20 to win $300 on any college basketball moneyline.

» Compare real-time odds here

March Madness Odds


Skip to:East | West | Midwest | South


First Four

#16 Norfolk State vs. #16 Appalachian State

  • Spread: App State -3
  • Total: 135.5
  • ML: +125/-145

#11 Drake vs. #11 Wichita State

  • Spread: Wichita State -2.5
  • Total: 139.5
  • ML: +115/-136

#16 Mount St. Mary's vs. #16 Texas Southern

  • Spread: Texas Southern -2
  • Total: 134
  • ML: +115/-136

#11 Michigan State vs. #11 UCLA

  • Spread: Michigan State -1
  • Total: 137.5
  • ML: -105/-115

West Region

#8 Oklahoma vs. #9 Missouri

  • Spread: Oklahoma -2
  • Total: 140.5
  • ML: -131/+110

#5 Creighton vs. #12 UC Santa Barbara

  • Spread: Creighton -7.5
  • Total: 140.5
  • ML: -301/+240

#4 Virginia vs. #13 Ohio

  • Spread: Virginia -10
  • Total: 132.5
  • ML: -530/+390

#3 Kansas vs. #14 Eastern Washington

  • Spread: Kansas -11.5
  • Total: 142.5
  • ML: -741/+520

#7 Oregon vs. #10 VCU

  • Spread: Oregon -5.5
  • Total: 138
  • ML: -261/+205

#2 Iowa vs. #15 Grand Canyon

  • Spread: Iowa -15.5
  • Total: 144.5
  • ML: -1500/+900

South Region

#1 Baylor vs. #16 Hartford

  • Spread: Baylor -26
  • Total: 142.5
  • ML: N/A

#8 North Carolina vs. #9 Wisconsin

  • Spread: North Carolina -2
  • Total: 138.5
  • ML: -121/+100

#5 Villanova vs. #12 Winthrop

  • Spread: Villanova -7
  • Total: 139
  • ML: -285/+225

#4 Purdue vs. #13 North Texas

  • Spread: Purdue -7.5
  • Total: 126
  • ML: -320/+245
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#6 Texas Tech vs. #11 Utah St.

  • Spread: Texas Tech -4.5
  • Total: 131.5
  • ML: -216/+170

#3 Arkansas vs. #14 Colgate

  • Spread: Arkansas -9.5
  • Total: 158.5
  • ML: -470/+350

#7 Florida vs. #10 Virginia Tech

  • Spread: Florida -1
  • Total: 137.5
  • ML: -121/+100

#2 Ohio State vs. #15 Oral Roberts

  • Spread: Ohio St. -16.5
  • Total: 154.5
  • ML: -2253/+1175

Midwest Region

#1 Illinois vs. #16 Drexel

  • Spread: Illinois -22.5
  • Total: 144
  • ML: N/A

#8 Loyola Chicago vs. #9 Georgia Tech

  • Spread: Loyola Chicago -2.5
  • Total: 127
  • ML: -140/+120

#5 Tennesse vs. #12 Oregon State

  • Spread: Tennessee -8.5
  • Total: 134
  • ML: -380/+290

#4 Oklahoma State vs. #13 Liberty

  • Spread: Oklahoma St. -9
  • Total: 145
  • ML: -460/+340
Photo by William Purnell/Icon Sportswire via Getty Images. Pictured: Cade Cunningham, Oklahoma State

#6 San Diego State vs. #11 Syracuse

  • Spread: San Diego St. -2
  • Total: 138
  • ML: -145/+125

#3 West Virginia vs. #14 Morehead State

  • Spread: West Virginia -12.5
  • Total: 137.5
  • ML: -851/+580

#7 Clemson vs. #10 Rutgers

  • Spread: Rutgers -1
  • Total: 127
  • ML: -105/-115

#2 Houston vs. #15 Cleveland St.

  • Spread: Houston -19
  • Total: 135
  • ML: N/A

East Region

#8 LSU vs. #9 St. Bonaventure

  • Spread: LSU -1.5
  • Total: 144.5
  • ML: -125/+105

#5 Colorado vs. #12 Georgetown

  • Spread: Colorado -5
  • Total: 138.5
  • ML: -200/+170

#4 Florida State vs. #13 UNC Greensboro

  • Spread: Florida St. -11
  • Total: 145.5
  • ML: -680/+480

#3 Texas vs. #14 Abilene Christian

  • Spread: Texas -8.5
  • Total: 140
  • ML: -440/+330

#7 Connecticut vs. #10 Maryland

  • Spread: Connecticut -2
  • Total: 130.5
  • ML: -136/+115

#2 Alabama vs. #15 Iona

  • Spread: Alabama -17
  • Total: 144.5
  • ML: -2000/+1100

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