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The Memphis Tigers take on the Vanderbilt Commodores in Nashville, TN. Tip-off is set for 7:15 p.m. ET on SEC Network+.
Vanderbilt is favored by -15.5 points on the spread with a moneyline of -2300. The total is set at 158.5 points.
Here’s my Memphis vs. Vanderbilt prediction and college basketball picks for November 10, 2026.
Memphis vs Vanderbilt Prediction
Pick: Over 158.5
My Memphis vs Vanderbilt best bet is on the over. Be sure to find the best lines by using our live NCAAB odds page and download the Action Network app for the latest picks and analysis.
Memphis vs Vanderbilt Odds
| Memphis Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+15.5 -105 | 158.5 -110o / -110u | +1060 |
| Vanderbilt Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-15.5 -115 | 158.5 -110o / -110u | -2300 |
- Memphis vs Vanderbilt spread: Vanderbilt -15.5 (-115), Memphis +15.5 (-105)
- Memphis vs Vanderbilt over/under: 158.5 (-110 / -110)
- Memphis vs Vanderbilt moneyline: Memphis +1060, Vanderbilt -2300
Memphis vs Vanderbilt College Basketball Preview
Memphis Basketball
Penny Hardaway is doing everything he can to get his boys ready as early as possible.
Nothing is going to overwhelm this Tigers team, as they have already played Mississippi State, Arkansas, Iowa State and VCU within the last two and a half weeks. The first two came in exhibitions in October, but still, every team Memphis has faced this season has been ranked inside the top 65 by Bart Torvik.
Haslametrics has the Tigers with the 17th-toughest schedule through the first week of the season. Typically, these highly ranked teams are playing their little brother's 14U teams to get the wheels turning, but not Hardaway's guys.
After losing 19 games last season, all Hardaway could do was two things: dig through the transfer portal and get his boys tested early.
It's going to be a lot of fun seeing how the Tigers pan out with the gauntlet they have ahead of them in non-conference play.
Vanderbilt Basketball
Vanderbilt has been taking care of business out of the gate, beating Bellarmine 93-47 in its season opener before following that up with a 74-51 win over Wake Forest.
This team is going to be a force in the SEC this season. You can already see Tyler Tanner leading the way for the Commodores. Not to mention sharpshooter Ace Glass, who is shooting 37.5% from deep early on.
The defensive tenacity this team plays with is a joy to watch.
Despite being favored by 15.5 points, this matchup against Memphis is a real test for the Commodores. I wouldn't be shocked to see the Tigers keep this one close.
Memphis vs. Vanderbilt Pick, Betting Analysis
"Colby, you spoke so highly of the Tigers above. Why not just take them to cover at +15.5?"
Yeah, I do lean toward Memphis. But early on, the Tigers have struggled on the defensive end. With this matchup likely turning into a track meet, considering both teams rank inside the top 100 in pace, the points are much more intriguing.
Through two games, Memphis has struggled to defend the perimeter and keep its hands to itself, ranking in the bottom 80 in both categories.
Luckily for us over bettors, Vanderbilt has struggled to get to the line and Memphis fouls often, so this could be the game where the Commodores generate some opportunities from the charity stripe.
Plus, they're shooting nearly 78% from the free-throw line early on.
Vanderbilt does have a fantastic defense, but with how fast this game is likely to be played, defense may take a back seat.
Pick: Over 158.5
