The Ball State Cardinals take on the Auburn Tigers in Auburn, Ala. Kickoff is set for 7:30 p.m. ET on ESPNU.
Auburn is favored by -43.5 points on the spread. The total is set at 52.5 points.
Here’s my Ball State vs. Auburn predictions and college football picks for Saturday, September 6, 2025.


Ball State vs Auburn Prediction
- Ball State vs. Auburn Pick: Over 52.5
My Auburn vs. Ball State best bet is on the over. Find the best line available on our live NCAAF odds page.
Ball State vs Auburn Odds
Ball State Odds | ||
---|---|---|
Spread | Total | Moneyline |
+43.5 -115 | 52.5 -102o / -118u | - |
Auburn Odds | ||
---|---|---|
Spread | Total | Moneyline |
-43.5 -105 | 52.5 -102o / -118u | - |
- Ball State vs Auburn point spread: Auburn -43.5
- Ball State vs Auburn over/under: 52.5 points

Ball State vs Auburn Pick, Betting Analysis
After beating Baylor by double digits in Waco, the Tigers have a couple of tune-up affairs with Ball State and South Alabama before SEC play.
Specifically for this affair against the Cardinals, a system is lighting up on the over.
Evan Abrams' "Unfamiliar Blowout Overs, No Wind" has a return on investment (ROI) of 17.6% since its inception, and it's eyeing this game to feature points galore.
"Unfamiliar Blowout Overs No Wind" is a college football system that identifies high scoring potential in non-conference games where large mismatches and calm weather create ideal conditions for offense.
During the regular season, when the home team is favored by more than 30 points, the talent gap often produces quick scoring opportunities and little resistance from the underdog.
The lack of conference familiarity further benefits the stronger team, as defensive preparation is weaker and big plays become more likely.
With the closing total set below 60, the market isn't fully pricing in the offensive potential of these lopsided matchups.
Calm conditions with wind speeds under ten miles per hour remove one of the biggest obstacles to scoring, making passing and kicking more efficient.
These factors combine to create a profile where the over consistently cashes as favorites pile on points and weaker opponents contribute through late scoring once the game is out of reach.
Pick: Over 52.5