Week 10 of the college football season is in full throttle, and it delivers some of the most anticipated matchups of the year, including another chapter of the Holy War and a crucial game between the Ducks and the Buckeyes.
This slate is headlined by the clash between the No. 1 Miami Hurricanes and No. 11 Notre Dame Fighting Irish, where the Irish surprisingly enter as heavy home favorites. Discover why in our comprehensive breakdown of the best picks and props to trade at Kalshi in Week 10.
Miami at Notre Dame: Odds, Spread and the Malachi Toney Factor
It is not every day that a consensus No. 1 team trades as an underdog against a program sitting outside the top 10 in the CFP Rankings. Yet that is precisely what is happening on the Kalshi markets for this Saturday’s matchup between Miami and Notre Dame.
The Fighting Irish host the Hurricanes as a 7.5-point favorite with 70% implied odds. That line movement intensified on November 4 following confirmation that Miami wide receiver Malachi Toney suffered a high ankle sprain, sending the Hurricanes’ implied chances tumbling from 34% down to their current 30% pricing.
Traders are weighing several key variables in fading Miami here. For starters, traveling into South Bend is never an easy assignment for any program. Adding to that hostile environment is the absence of Toney, a cornerstone weapon in the Hurricanes' offensive scheme.
Sources report that Toney could ultimately suit up and see the field, though those rumors remain unconfirmed. If he does play, expect the odds to see one final shift before kickoff.
However, the decisive catalyst lies in situational motivation. While both programs are playing to win, for Notre Dame this contest represents an absolute must-win scenario to keep its College Football Playoff hopes alive. Expect a fiercely contested, physical battle in the trenches.
In this context, backing Notre Dame as a home favorite is the way to go. Also take them at -7.5, the Irish will cover it by the end of the night.
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Georgia at Ole Miss: The Big SEC Showdown Odds
Georgia trades as a 3.5-point road favorite against Ole Miss. Right now, Kalshi’s board assigns Georgia a 61% implied chance, but the matchup was far tighter just days ago when the Bulldogs traded at 56% and the Rebels held 44%.
Right out of the gate, expect an explosive and hard-fought contest. Adding fuel to the matchup, Ole Miss has Trinidad Chambliss fully back in form. The playmaker has delivered stellar performances over recent weeks after moving past a rough stretch that had briefly derailed his rhythm.
The recent series history is dead even, with the programs splitting their last six meetings. However, Ole Miss claimed the defining victory in 2026, taking down the Sugar Bowl to punch their ticket to the College Football Playoff semifinals.
Georgia’s moneyline looks inflated by their standing in the CFP rankings. Between home-field advantage in Oxford and Chambliss operating at peak level, backing Ole Miss seems like the best option. Also target the over on 57.5, and call it a night.
Kickoff is scheduled for 7:30 p.m. ET at Vaught-Hemingway Stadium.
Alabama at LSU: What’s at Stake?
This Saturday, No. 5 Alabama travels to Death Valley to face No. 14 LSU. Playing under the lights in Baton Rouge presents a road test for the Crimson Tide's offense, which must establish a balanced ground attack to neutralize LSU’s edge rushers. With both teams sitting on two losses, there is no margin for error.
LSU enters as a 6.5-points home favorite trading with 67% implied odds. Over the last few days, the gap between both teams slowly grew bigger. Back on November 1, Alabama was priced at 38% implied odds, and now they have fallen to 33%.
The spread is the most interesting angle here. LSU boasts a highly dynamic and powerful defense that will be met with Alabama’s systematic offensive weaknesses. In that context, the Tigers can perfectly cover the -6.5 spread at home.
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BYU at Utah: The Big 12 Holy War at Noon
The Holy War will take place in Salt Lake City as No. 7 BYU visits archrival, No. 3 Utah, in a high-stakes Big 12 showdown that will be the first top-10 matchup in the history of the series. Right now, the Utes trade as road favorites with 61% odds on the moneyline.
Rice-Eccles Stadium will test the undefeated Cougars, whose offense relies heavily on quarterback Bear Bachmeir intelligence and explosive plays to inflict damage early in the game. The Utes counter with their trademark brand of suffocating defense and a ground game engineered to control time of possession.
When these rivals collide, you can typically expect a physical, low-scoring trench fight. My favorite position on the board is targeting the Under 48.5 on totals. While I agree with the moneyline consensus, this will be a tightly contested affair decided by the slimmest of margins. Backing Utah to cover -3.5 on the spread is my pick.
The game between BYU and Utah is set for this Saturday, November 7, with kickoff scheduled for 12:00 p.m. ET.
Oregon at Ohio State: The Buckeyes Will Bounce Back?
This Saturday at 3:30 p.m. ET, No. 12 Ohio State hosts No. 23 Oregon in a high-stakes clash where both programs need a win to keep their playoff hopes alive. Backed by home-field advantage and the need for a bounce-back victory, the Buckeyes enter as 7.5-point home favorites, with 72% implied odds on Kalshi.
The Buckeyes' five-game winning streak snapped against USC last weekend, a crushing blow that impacted their standing in the CFP rankings, dropping them to No. 12 and leaving them on the brink of playoff elimination. However, I expect Ohio State to bounce back immediately, and this home tilt serves as the ideal scenario for that.
My two favorite positions on the board are Ohio State laying the 9.5 points to cover the spread and the Over on 46.5 total points. Backing both angles might sound overly enthusiastic on the Buckeyes, but I think they are set to deliver a statement win this Saturday.
