The Florida Gators take on the LSU Tigers in Baton Rouge, Louisiana. Kickoff is set for 7:30 p.m. ET on ABC.
LSU is favored by 7 points on the spread with a moneyline of -285. The total is set at 46.5 points.
Here’s my Florida vs. LSU prediction and college football picks for Saturday, September 13, 2025.
Florida vs LSU Prediction
- Florida vs. LSU Pick: Florida +7 (-105, BetMGM)
My LSU vs. Florida best bet is on the Gators to cover the spread. Find the best line available on our live NCAAF odds page.
Florida vs LSU Odds
| Gators Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -105 | 46.5 -110o / -110u | +225 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -115 | 46.5 -110o / -110u | -285 |
- Florida vs LSU point spread: LSU -7
- Florida vs LSU over/under: 46.5 points
- Florida vs LSU moneyline: Florida +225, LSU -285
Florida vs LSU Preview
Florida Gators Betting Preview: Don't Be Alarmed
Florida reared its ugly head last week in the 19-18 loss against South Florida.
Granted, South Florida has given blue bloods’ headaches for the past few seasons, so this shouldn’t come as a surprise.
All things considered, the Gators have still been a solid defensive team, ranking sixth nationally in Rush Success Rate allowed and 11th in Pass Down Success Rate allowed.
We’ll talk more about how this will end up impacting the game, but defensive backs Bryce Thornton and Devin Moore are definitely players to keep an eye on.
Despite all the criticism Florida has gotten after the loss, I still think this is a quality football team.
DJ Lagway has said he plans on fixing the early-season woes, and even though talk can be cheap, I don’t think it’s out of the question. His quarterback rating may be low, but he’s completed 74% of his passes and has only turned the ball over once.
He had to play LIU in the first game, so OK, I’ll give you that. But you saw flashes of his potential last season.
In addition, he has an exceptional run game behind him with Jadan Baugh receiving most of the carries at an impressive 7.3 yards per carry. I was also a fan of Ja’Kobi Jackson last season, who can serve as a solid backup.
In the receiving game, Vernell Brown III has done a great job, averaging 17 yards per catch on eight receptions. At the same time, tight end Hayden Hansen and receiver Eugene Wilson III have collected the majority of touchdowns through the air.
LSU Tigers Betting Preview: A Shaky 2-0 Start
In a massive development for the Tigers, starting center Braelin Moore is listed as “Probable” on the injury report.
Moore rolled his ankle on the first play of the game against Louisiana Tech and didn’t see the rest of the game. However, for the big-time SEC matchup, all systems go.
Quarterback Garrett Nussmeier is looking to build on a solid start to the season, where he leads the SEC in total completions. However, the one problem with Nussmeier is his propensity to turn the ball over.
Last season, he led the SEC in interceptions with 13, and at one point threw two or more interceptions in five consecutive games.
Given Florida’s appetite for destruction on the defensive end, I wouldn’t be surprised if we see another interception.
Nussmeier may be losing one of his bigger targets as well in tight end Trey’Dez Green. Green injured his knee in the fourth quarter last week and was seen on crutches. However, coach Brian Kelly revealed that it was a sprained MCL and will list him as questionable.
If I had to guess, we don’t see Green tonight, just for the sole fact that next week, LSU has to face FCS Southern Louisiana, which should be a walk in the park. Following that week will be Ole Miss, which would be a good time for his return.
While passing touchdowns have escaped the Tigers so far in the first two weeks, Aaron Anderson has been the go-to guy for Nussmeier, averaging 12.4 yards per catch on 14 receptions. And Barion Brown has similarly been a favorite target of his as well.
The defense is good, ranking 11th nationally in Pass Down Success Rate allowed and 22nd in Pass Success Rate allowed.
Cornerback Mansoor Delane has been a standout so far this season, recording an interception and three pass breakups. Along with that, linebacker West Weeks has been a force with 13 total tackles and a tackle for loss.
Florida vs LSU Pick, Betting Analysis
I’m not as bullish on LSU as most.
It was impressive to see the Tigers limit Clemson to 10 points in Week 1, but only scoring 23 points against Louisiana Tech was a bit worrisome.
Meanwhile, Florida struggled against a program that is always tough against upper-echelon competition.
It may be a bad look in the grand scheme of things that the Gators fell to the Bulls, but overall, it shouldn’t be that big of a deal.
Especially with Nussmeier’s high-end ability to turn the ball over, I think Florida’s defense will have the Tigers in a stranglehold.
Did I mention that LSU’s run game is nonexistent? The Tigers' lead rusher, Caden Durham, only averages 3.4 yards per carry, which opens the door for Florida’s defensive line to feast.
The spread is too big, and I think Florida covers — or wins outright.
Pick: Florida +7 (-105, BetMGM)
