The Louisiana Tech Bulldogs take on the LSU Tigers in Baton Rouge, LA. Kickoff is set for 7:30 p.m. ET on SEC Network+.
LSU is favored by -37.5 points on the spread with a moneyline of -6600. The total is set at 51.5 points.
Here’s my Louisiana Tech vs. LSU predictions and college football picks for Saturday, September 6, 2025.
Louisiana Tech vs LSU Prediction
- Louisiana Tech vs. LSU Pick: Over 51.5
My LSU vs. Louisiana Tech best bet is on the over. Find the best line available on our live NCAAF odds page.
Louisiana Tech vs LSU Odds
| Louisiana Tech Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+37.5 -115 | 51.5 -105o / -115u | +1650 |
| LSU Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-37.5 -105 | 51.5 -105o / -115u | -6600 |
- Louisiana Tech vs LSU point spread: LSU -37.5
- Louisiana Tech vs LSU over/under: 51.5 points
Louisiana Tech vs LSU Pick, Betting Analysis
LSU pulled off a quality season-opening victory over Clemson on the road to boast its ranking to No. 3 in the AP Poll.
Garrett Nussmeier and company now have a buy-game against Louisiana Tech before hosting Florida next week to start SEC play.
That doesn't mean the Tigers won't have their foot on the gas pedal in this one.
In fact, a system — Evan Abrams' "Unfamiliar Blowout Overs, No Wind" — is lighting up on the over in this affair.
"Unfamiliar Blowout Overs No Wind" is a college football system that identifies high scoring potential in non-conference games where large mismatches and calm weather create ideal conditions for offense.
During the regular season, when the home team is favored by more than 30 points, the talent gap often produces quick scoring opportunities and little resistance from the underdog. The lack of conference familiarity further benefits the stronger team, as defensive preparation is weaker and big plays become more likely.
With the closing total set below 60, the market isn't fully pricing in the offensive potential of these lopsided matchups.
Calm conditions with wind speeds under 10 miles per hour remove one of the biggest obstacles to scoring, making passing and kicking more efficient.
These factors combine to create a profile where the over consistently cashes as favorites pile on points and weaker opponents contribute through late scoring once the game is out of reach.
Pick: Over 51.5
