HomeRight ArrowNCAAF

Mississippi State vs South Carolina Prediction, Odds, Picks Today: College Football Week 3

Mississippi State vs South Carolina Prediction, Odds, Picks Today: College Football Week 3 article feature image
2 min read
Credit:

Sep 12, 2026; Minneapolis, Minnesota, USA; Mississippi State Bulldogs quarterback Kamario Taylor (1) breaks the tackle attempt of Minnesota Golden Gophers defensive back John Nestor (17) during the fourth quarter at Huntington Bank Stadium. Mandatory Credit: Nick Wosika-Imagn Images

The Mississippi State Bulldogs take on the South Carolina Gamecocks in Columbia, South Carolina. Kickoff is set for 4:15 p.m. ET on the SEC Network.

South Carolina is favored by 3.5 points on the spread with a moneyline of -162. The total is set at 58.5 points.

Here’s my Mississippi State vs. South Carolina prediction and college football pick for Saturday, September 19.


Mississippi State Bulldogs vs South Carolina Gamecocks Prediction, Picks

  • Mississippi State vs. South Carolina Pick: Mississippi State +3.5 or Better

My South Carolina vs. Mississippi State best bet is on the Bulldogs. Find the best line available on our live NCAAF odds page.


Mississippi State vs South Carolina Odds, Betting Line, Point Spread

Mississippi State Logo
Saturday, Sept. 19
4:15 p.m. ET
SEC Network
South Carolina Logo
Mississippi State Odds
SpreadTotalMoneyline
+3.5
-112
59.5
-105o / -115u
+145
South Carolina Odds
SpreadTotalMoneyline
-3.5
-108
59.5
-105o / -115u
-175
Odds via DraftKings. Get up-to-the-minute NCAAF odds here.
DraftKings Logo


Header First Logo
Header Second Logo

Mississippi State vs South Carolina Pick, Preview

This game triggered one of our Action PRO betting systems, powered by Evan Abrams:

CFB Sharp Money Fade in NCAAF Spread tells the story of a regular-season college football matchup where the betting market appears to signal confidence from larger wagers, but that signal has become less reliable in recent years.

When the difference between money share and ticket share grows large, it traditionally implied that influential bettors were backing one side while the public leaned the other way. In the modern college football market, however, information moves quickly, and public participation has grown, creating situations where perceived sharp indicators can actually represent late crowd momentum rather than true professional conviction.

When the number of bets sits in a moderate range, the market has enough activity to shape perception but not enough depth to fully stabilize the price. In this environment, fading the side attracting the disproportionate money support becomes a contrarian stance that assumes the market has overreacted to what looks like smart action, allowing the opposite team to quietly outperform expectations once the game unfolds on the field.

Pick: Mississippi State +3.5 or Better


Mississippi State vs South Carolina Trends to Know



Mississippi State vs South Carolina Weather Forecast


Get the latest coverage on NCAAF Weather.
Action PRO Upsell Image
Premium picks, tools & analysis
Track & follow smart money
Biggest player prop edges
Real-time expert pick alerts
Author Profile
About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.