The Ohio Bobcats take on the Eastern Michigan Eagles in Ypsilanti, Michigan. Kickoff is set for 12:00 p.m. EDT on CBS Sports Network.
Ohio is favored by 11.5 points on the spread with a moneyline of -450. The total is set at 58.5 points.
Here’s my Ohio vs. Eastern Michigan prediction and college football picks for Saturday, October 25, 2025.
Ohio vs Eastern Michigan Prediction
- Ohio vs. Eastern Michigan Pick: Ohio -11.5 (-110, bet365)
My Eastern Michigan vs. Ohio best bet is on the Bobcats to cover. Find the best line available on our live NCAAF odds page.
Ohio vs Eastern Michigan Odds
| Ohio Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-11.5 -110 | 58.5 -110o / -110u | -450 |
| Eastern Michigan Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+11.5 -110 | 58.5 -110o / -110u | +350 |
- Ohio vs Eastern Michigan point spread: Ohio -11.5 (-110), E. Michigan +11.5 (-110)
- Ohio vs Eastern Michigan over/under: 58.5 (-110o / -110u)
- Ohio vs Eastern Michigan moneyline: Ohio -450, Eastern Michigan +350.
Ohio vs Eastern Michigan Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
The Right Favorite is a college football system built on recognizing when the betting market underestimates a favorite.
In the regular season, when an opponent is coming off a loss by seven to 23 points, perception often inflates their chances of rebounding. Yet, those weaknesses typically carry into the next game.
By focusing on contests where the total is set over 55, the system narrows in on higher-scoring games, making it more difficult for struggling teams to keep pace.
Limiting the sample to the first 11 games of the season ensures the analysis applies before postseason adjustments in motivation and preparation occur.
Finally, the spread filter targets situations where the line is set with the other side catching points, but not in extreme ranges, allowing favorites to deliver consistent covers.
Together, these conditions create a profile where the favorite is positioned as the stronger play despite public bias suggesting otherwise.
Teams that have fit this system are 13-7 ATS this year (65% win rate, 24% ROI). Five of the last six teams to fit this system have covered.
Pick: Ohio -11.5 (-110, bet365)
