Oklahoma State vs. ISU Spread Pick, Prediction Saturday of College Football Week 4

Oklahoma State vs. ISU Spread Pick, Prediction Saturday of College Football Week 4 article feature image
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Credit: Brian Bahr/Getty Images Pictured: Oklahoma State’s Collin Oliver and Jaden Bray.

Saturday, Sep 23
4:00pm ET
Fox Sports 1
OK State Odds
SpreadTotalMoneyline
+3.5
-110
36.5
-112o / -108u
+145
Iowa State Odds
SpreadTotalMoneyline
-3.5
-110
36.5
-112o / -108u
-175
Odds via DraftKings. Get up-to-the-minute NCAAF odds here.

The spread in Saturday's Oklahoma State vs. Iowa State game suggests it will be the tightest matchup among Big 12 college football games in Week 4.

Believe it or not, there's a massive betting edge to consider.

Today's Oklahoma State vs. Iowa State betting spread fits a 60% college football model in Bet Labs.

And it's one of my favorites, only making predictions against the spread.

The Cowboys are small road underdogs in Ames, Iowa.

Oklahoma State has been a top-10 best bet nationally against the spread the last five-plus seasons.

After ISU rattled off four straight against the spread in the series, the Cowboys enter Week 4 with four straight covers over the Cyclones.

One of the biggest betting nuggets to Saturday's Oklahoma State vs. ISU spread pick is how both offenses fared in their last matchup.


Oklahoma State vs. Iowa State Spread Prediction