The South Alabama Jaguars take on the Tulane Green Wave in New Orleans, LA. Kickoff is set for 7 p.m. ET on ESPN+.
Tulane is favored by -9.5 points on the spread with a moneyline of -350. The total is set at 49.5 points.
Here’s my South Alabama vs. Tulane prediction and college football pick for Saturday, September 12, 2026.
South Alabama vs Tulane Prediction
- South Alabama vs. Tulane Pick: Over 49.5
My Tulane vs. South Alabama best bet is on the over. Find the best line available on our live NCAAF odds page.
South Alabama vs Tulane Odds
| South Alabama Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+9.5 -115 | 49.5 -108o / -110u | +275 |
| Tulane Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-9.5 -105 | 49.5 -108o / -110u | -350 |
- South Alabama vs Tulane point spread: Tulane -9.5 (-105), South Alabama +9.5 (-115)
- South Alabama vs Tulane over/under: 49.5 (-108o / -110u)
- South Alabama vs Tulane moneyline: South Alabama +275, Tulane -350
South Alabama vs Tulane Pick, Betting Analysis
South Alabama had a successful first game of the season, as it mauled SE Louisiana from the jump, winning 39-14.
But now the competition level jumps up a bit as the Jaguars travel to the Big Easy to take on Tulane.
The Green Wave barely were able to put together any offense in their first game of the season, scoring just three points against Duke on the road. Their run defense had no chance against Duke running back Nate Sheppard, as he ran for 227 yards and scored two touchdowns on 35 attempts.
While Tulane played a low-scoring 20-total-point game in its opener, our very own Evan Abrams has a Bet Labs Sports Insights system that says the over is the play for South Alabama vs. Tulane.
In fact, this system — "Beware of Falling Totals" — has been very reliable over time, with a 247-208-6 overall record (54%) and a 4% return on investment (ROI). Just this season alone (in a small sample size), it has a 19% ROI on a 5-3 record.
In both regular season and postseason college football, significant drops in the total from opening to closing lines often reflect heavy betting on the under, usually driven by weather concerns, injuries or perceived matchup issues.
However, these moves can sometimes overstate the expected scoring decline, creating value on the over.
When the adjustment is meaningful but not extreme, offenses can still exceed the lowered expectation, particularly if conditions improve or if the line movement was influenced by public overreaction rather than substantial changes to game dynamics.
Expect points!
Pick: Over 49.5
