Buccaneers vs. Bills Odds & Betting Predictions - November 16, 2025

Buccaneers at Bills

6:00 pm • CBS

Tampa Bay Buccaneers

@

Buffalo Bills

MatchupOpenSpreadTotalMoneyline
Buccaneers 5-2	N/A	N/A	N/A
Bills 4-2	N/A	N/A	N/A

location pin

Sunday 6:00 p.m.

November 16, 2025

Highmark StadiumOrchard Park

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NFL Public Betting

Bills are 4-1 in their last 5 games.
Bills are 2-3 in their last 5 games against the spread
Bills are 1-1 in their road games against the spread
The totals have gone OVER in 3 of Bills' last 5 games
The totals have gone OVER in 3 of Bills' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Bills	2-4	1-3	1-1	1-4	1-0
Buccaneers	4-3	1-2	3-1	2-1	2-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Bills	3-3	3-1	0-2	2-3	1-0
Buccaneers	4-3	3-0	1-3	2-1	2-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Bills	4-2	N/A	N/A	3-2	1-0
Buccaneers	5-2	N/A	N/A	3-0	2-2

date	opponent	score	spread	over/under	moneyline
Oct 13th	@ATL	L 14-24	-3.5 L	U 49.5	ATL -202
Oct 6th	NE	L 20-23	-7.5 L	U 48.5	NE -430
Sep 28th	NO	W 31-19	-14.5 L	O 48.5	BUF -1500
Sep 19th	MIA	W 31-21	-11.5 L	O 50.5	BUF -800
Sep 14th	@NYJ	W 30-10	-6 W	U 47.5	BUF -290

Mike Evans
WR
Evans is out with collarbone
Out
Chris Godwin
WR
Godwin is out with leg
Out
Ko Kieft
TE
Kieft is out with leg
Out
Christian Izien
S
Izien is out with oblique
Out
Bucky Irving
RB
Irving is out with foot
Out
Benjamin Morrison
CB
Morrison is out with quad
Out

Curtis Samuel
WR
Samuel is questionable with ribs
Questionable
Mitch Wishnowsky
P
Wishnowsky is out with back
Out
Tyler Bass
K
Bass is out with hip
Out
Joshua Palmer
WR
Palmer is out with ankle
Out
Dalton Kincaid
TE
Kincaid is questionable with oblique
Questionable

See more NFL Injuries

passing yards
Josh Allen
1397
pyds
passing touchdowns
Josh Allen
11
ptd
rushing yards
James Cook
537
ryds
rushing touchdowns
James Cook
5
rtd

	Starter	2ND	3RD	4TH
QB	Josh Allen	Mitchell Trubisky	Shane Buechele
RB	James Cook	Ray Davis	Ty Johnson	Frank Gore
WR	Khalil Shakir	Elijah Moore	Stephen Gosnell
TE	Dalton Kincaid	Dawson Knox	Jackson Hawes	Keleki Latu
LT	Dion Dawkins	Tylan Grable	Chase Lundt	Travis Clayton
LG	David Edwards	Kendrick Green
C	Connor McGovern	Sedrick Van Pran-Granger
RG	O'Cyrus Torrence	Alec Anderson
RT	Spencer Brown	Ryan Van Demark
LDE	Greg Rousseau	Landon Jackson	Javon Solomon
WLB	Matt Milano	Dorian Williams	Keonta Jenkins
MLB	Terrel Bernard	Joe Andreessen	Shaq Thompson	Jimmy Ciarlo
LCB	Christian Benford	Maxwell Hairston	Dorian Strong
SS	Cole Bishop	Cam Lewis	Wande Owens
FS	Taylor Rapp	Damar Hamlin	Jordan Hancock
RCB	Tre'Davious White	Dane Jackson	Ja'Marcus Ingram
PR	Brandon Codrington
KR	Brandon Codrington	Elijah Moore
LS	Reid Ferguson
NB	Taron Johnson	Brandon Codrington
NT	DaQuan Jones	Deone Walker	Zion Logue
DT	Ed Oliver	T.J. Sanders	DeWayne Carter
LWR	Joshua Palmer	Tyrell Shavers
FB	Reggie Gilliam
K	Tyler Bass
RWR	Keon Coleman	Curtis Samuel	Kristian Wilkerson

Total

Passing

1675

YDS

1364

157/245

Comps/Atts

123/180

7.212

YPA

7.939

13/2

TDs/INTs

11/4

14/92

Sacks/Yards

12/65

Rushing

697

Rush Yards

906

175

Attempts

186

3.983

YPC

4.871

5

TDs

9

Turnovers

Fumbles Lost

2

Interceptions

4

Efficiency

10/20 50%

Redzone

16/25 64%

34/89 0%

3rd Down

28/68 0%

5/10 0%

4th Down

3/5 0%

First Downs

137

Total

139

78

Pass

73

40

Rush

50

19

Penalty

16

Misc

/

Penalties/Yards

/

Possession

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MatchupOverUnder
Buccaneers 5-2	N/A	N/A
Bills 4-2	N/A	N/A