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Saints vs Titans Prediction, Pick, Odds for NFL Week 17

Saints vs Titans Prediction, Pick, Odds for NFL Week 17 article feature image
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Action Network/Imagn Images: Tyler Shough, Cam Ward

The New Orleans Saints (5-10) and Tennessee Titans (3-12) will face off in NFL Week 17. Kickoff is set for 1:00 p.m. ET from Nissan Stadium in Nashville, Tenn. The game will be broadcast live on CBS.

The Saints are favored by -2.5 on the spread; the over/under is 39.5 points. The Saints are a -148 favorite to win on the moneyline, while the Titans are +124 to pull off the upset.

Let's get into my Saints vs Titans prediction for today's Week 17 game.


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Saints vs Titans Prediction

  • Saints vs Titans pick: Over 39.5

My Saints vs Titans best bet is the game total to go over 39.5 points. Find the best odds by checking our live NFL odds page.


Saints vs Titans Odds

Saints Logo
December 28, 2025
1:00 p.m. EST
CBS
Titans Logo
Saints Odds
SpreadTotalMoneyline
-2.5
-105
39.5
-110o / -110u
-148
Titans Odds
SpreadTotalMoneyline
+2.5
-115
39.5
-110o / -110u
+124
Odds via bet365. Get up-to-the-minute NFL odds here.
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Saints vs Titans Week 17 Preview

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Saints Betting Preview: Shough Finds His Way

The Saints have been one of the more interesting teams in the NFL during the latter half of the season. The development of quarterback Tyler Shough into a viable starter heading into 2026 and beyond has been the headline, but their defense deserves credit for how well it has played in recent weeks.

New Orleans has allowed just 4.4 yards per play to opposing offenses since Week 10 — the best mark in the NFL over that span. However, some context is required.

The Buccaneers' Baker Mayfield is the best quarterback they’ve faced during that stretch, and even he wasn’t at full health or surrounded by his usual supporting cast.

Three of those games came at home against Bryce Young, Kirk Cousins and Brady Cook. Their lone road game in that span came against Tua Tagovailoa, who attempted just 23 passes in a win. One week prior, in Week 9, the Saints surrendered 34 points on the road.

Saints head coach Kellen Moore has consistently brought a high-paced attack to his offenses, and the Saints are no exception despite a rookie quarterback under center. New Orleans leads the NFL in pace across nearly every category and is coming off a performance against the Jets in which it called pass plays at a season-high 12% above expectation.

With Shough completing 68% of his passes since Week 10, it’s fair to expect Moore to again lean on the passing game, potentially pushing his quarterback toward 40 attempts.


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Titans Betting Preview: Ward Capping Season on High Note

While Cam Ward isn’t necessarily a tier above the quarterbacks New Orleans has faced recently, he has been playing better of late, and the game plans from Titans interim head coach Mike McCoy and offensive coordinator Nick Holz have reflected that improvement.

Ward has thrown multiple touchdown passes in three consecutive games, with the offense scoring 10 times over that span. He’s also coming off his most efficient performance of the season, setting career highs in both completion percentage and yards per attempt last week.

As a result, the coaching staff has opened things up compared to the first three quarters of the season. Tennessee’s offense played at the slowest neutral pace in the league earlier in the year, but over the last month, that pace has climbed to 23rd.

This is particularly relevant against a Saints team that will gladly push the tempo.

Tennessee’s defense has been sound against the run, but it ranks 28th in pass defense success rate. This unit functions as a classic pass-funnel, prioritizing run defense while allowing a high volume of completions through the air.

The Titans rank 29th in yards per attempt allowed (7.9), and opposing quarterbacks have posted a collective 104.4 passer rating against them, the fourth-worst mark in the NFL.


Saints vs Titans Prediction, Betting Analysis

With play volume working in our favor and the confidence of each offensive staff in its quarterback continuing to rise, I’m expecting points to be put on the scoreboard in this matchup. On what’s forecasted to be a near 70-degree day in Nashville, conditions are ripe for an over.

Three of the last five games involving Tennessee have seen the over cash, with the two unders in that span coming in games where one of the teams failed to reach double-digit points. That shouldn’t be the case for either offense in this spot.

Pick: Over 39.5

Playbook

Spread

I have no play for either side of the spread.

Moneyline

I'm also passing on the moneylines.

Over/Under

I like this game to go over the total.


Saints vs Titans Betting Trends


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Author Profile
About the Author

John Lanfranca is a contributor at Action Network who specializes in NFL betting, with a focus on sides, totals, and player props. He has been betting since 2006 John has been involved with football since a young age and currently coaches at the high school level. He has cashed multiple five-figure entries in NFL DFS, which coincided with him entering the industry with Fantasysharks, where he contributed as a podcaster while also writing daily articles on betting, DFS, and the NFL Draft. John has shown a consistent ability to win when betting the NFL against the spread, regularly finishing seasons with a winning percentage in the 55-60% range

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