NFL Odds: Lines for Every Week 1 Matchup, Including Bills vs Rams, Packers vs Vikings, Buccaneers vs Cowboys, More

Starting this week and going until the end of January, we are going to have NFL football every single week.

Week 1 is set to open with a bang as two Super Bowl favorites, including the reigning champions, face off in Los Angeles, where the Rams host the Bills. Sunday Night Football brings a crazy matchup with the Buccaneers and Cowboys, before Russell Wilson's return to Seattle with the Broncos is on Monday Night Football.

Obviously, you're itching to get going with the NFL season. That's why you're here.

Here are the odds for every single game in Week 1. Enjoy.

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NFL Week 1 Odds

Bills vs.

Rams

The Bills are the Super Bowl favorites across the board, and the Rams are the reigning champions. We'll start the season where the last one ended: SoFi Stadium.

Saints vs.

Falcons

New Orleans starts a new era without Sean Payton, and there are plenty of reasons for optimism. Jameis Winston, who was thriving before suffering a torn ACL last year, is back, and he'll add Michael Thomas and rookie Chris Olave to his receiving corps. Atlanta, well, doesn't have the same positive outlook about its season.

49ers vs.

Bears

The Trey Lance era officially begins in the Windy City. San Francisco fell one game short of the Super Bowl last season and is now all-in on last year's No. 3 overall pick. The Bears will hope their second-year QB takes a step forward, although the playmakers around Justin Fields have created doubts about Chicago this season.

Steelers vs.

Bengals

While the Trey Lance era begins, it's fair to say this isn't the Mitch Trubisky era beginning for Pittsburgh. Still, Ben Roethlisberger is gone and Trubisky will start the season under center with rookie Kenny Pickett lurking. The Steelers face a tough test with the Bengals, who improved their offensive line and will look to build off a Super Bowl appearance.

Eagles vs.

Lions

Both the Eagles and Lions are optimistic entering this season. Philadelphia added A.J. Brown to its offense and is hoping Jalen Hurts can take it to the next level: The playoffs. Detroit, meanwhile, is simply hoping to win seven or eight games. The Lions have plenty of offensive playmakers and No. 2 overall pick Aidan Hutchinson to lead the defense.

Patriots vs.

Dolphins

New England hopes to give Mac Jones more responsibility in Year 2, as it looks to reclaim the AFC East. In Miami, expectations are high for the Dolphins' offense. Tua Tagovailoa has a new head coach in Mike McDaniel and a new elite weapon in Tyreek Hill. We'll find out if that's enough to best New England right away.

Ravens vs.

Jets

There are injury concerns for both teams entering Week 1, although they're bigger for the Jets. QB Zach Wilson was the No. 2 overall pick last year, and New York will go as he goes this season. He recently had knee surgery, though, and his status for this game is unknown. Baltimore's uncertainty comes in the form of RB J.K. Dobbins, although the Ravens will have a healthy Lamar Jackson for this one.

Jaguars vs.

Commanders

Something's gotta give in this one. It can't get much worse than last season for the Jaguars, who are hoping new head coach Doug Pederson will bring out the best in Trevor Lawrence. In Washington, the Commanders have put their faith in Carson Wentz — a bold strategy.

Browns vs.

Panthers

One of two potential revenge games this week. Baker Mayfield will hope he can lead his new team, the Panthers, against the Browns, who traded for Deshaun Watson and gave him a fully guaranteed contract while Mayfield was on the roster.

Colts vs.

Texans

Matt Ryan will begin his Colts career in Houston against a Texans roster that looks … underwhelming. Don't expect the Texans to be favored in any game this season. This season will be a success if they're positioned to draft an elite quarterback prospect in 2023 or Davis Mills takes a step forward.

Giants vs.

Titans

Can Brian Daboll put Daniel Jones on a positive career path? That's what the Giants are banking on. The new head coach has a tough first test in his debut, facing last year's top seed in the AFC. Derrick Henry is healthy, but the Titans' offense faces uncertainty in the passing game without A.J. Brown.

Packers vs.

Vikings

America's Game of the Week. Matt LaFleur has won 13 regular-season games in each of his first three years in Green Bay, but people are skeptical due to underwhelming analytics and the loss of wide receiver Davante Adams. The Vikings, though, have a new offensive-minded head coach in Kevin O'Connell, who fans hope can unleash Kirk Cousins and take Minnesota's offense to the next level.

Chiefs vs.

Cardinals

Like the Packers, the Chiefs have to replace their top receiver with Tyreek Hill in Miami now. Kansas City faces a tough trip to the desert, where Kyler Murray will make his first start after "Studygate" and his new contract extension. Kansas City is favored because Patrick Mahomes is Patrick Mahomes, and any potential decrease in production from the Chiefs' offense needs to be seen before believing.

Raiders vs.

Chargers

This game is a rematch of last year's Week 18 matchup that saw the winner get into the playoffs. Las Vegas won that game, but people are much higher on the Chargers entering this season. Los Angeles added OLB Khalil Mack and CB J.C. Jackson to bolster a defense that was below average last year, while the Raiders traded for Davante Adams and have a new head coach in Josh McDaniels. This one should be good.

Buccaneers vs.

Cowboys

Tom Brady against "America's Team" is about what you'd expect for the first Sunday Night Football game of the season. Brady, as you may have heard, took an unexplained, but excused, weeklong leave from training camp last month, which has people debating how high they should be on Tampa Bay. The Cowboys, meanwhile, are the favorites in the NFC East and should be strong on both sides of the ball.

Broncos vs.

Seahawks

This is the second revenge game I mentioned earlier, although this time it'll be the QB's former team with the most motivation. After 10 seasons and a 104-53-1 record with Seattle, Wilson is now leading a Broncos team that seems like it's been a quarterback away over the past couple years. The Seahawks are expected to be among the NFL's cellar-dwellers this season, but they'll no doubt be looking to ruin Wilson's Broncos debut.