Week 4 features an NFC West rivalry game between the Seattle Seahawks and Arizona Cardinals on Thursday Night Football. Seahawks vs Cardinals is scheduled to kick off at 8:15 p.m. ET at State Farm Stadium. The game will be broadcast on Prime Video.
The Cardinals originally opened as 2.5-point favorites for Thursday Night Football, but the odds have swung the other way. The Seahawks are 1.5-point favorites on the spread over the Cardinals (Seahawks -1.5) with a game total of 43.5. The Seahawks are -125 moneyline favorites and the Cardinals are +105 underdogs.
Below, you can find our Seahawks vs Cardinals predictions for Thursday Night Football.
Seahawks vs Cardinals Predictions & Picks
| Game | Time (ET) | Best Bet |
|---|---|---|
  | 8:15 p.m. | |
| 8:15 p.m. | |
| 8:15 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Seahawks vs Cardinals Odds
- Seahawks vs Cardinals Moneyline: Seahawks -125, Cardinals +105
- Seahawks vs Cardinals Spread: Seahawks -1.5 (-110), Cardinals +1.5 (-110)
- Seahawks vs Cardinals Over/Under: 43.5 (-110o / -110u)
NFL odds via bet365
Seahawks vs Cardinals Against the Spread Prediction
By Billy Ward
There’s a strange amount of symmetry between the Cardinals and the Seahawks.
The 2-1 teams both have wins over the Saints, who may be the NFL’s worst team at the moment. Both team’s lone loss also came in tight games to the 49ers, with the Seahawks losing in Week 1 and the Cardinals in Week 3.
I view that as the big difference in these team’s records.
The Week 1 version of San Francisco had George Kittle, Brock Purdy and a full game of Nick Bosa, while the Week 3 version that beat the Cardinals did not. Additionally, the Seahawks' other win was over the Steelers, while the Cardinals beat the Panthers.
Seattle’s net-point differential on the season is +41, 30 points higher than the Cardinals despite facing tougher competition (when you adjust for the 49ers' health). That explains why our Luck Rankings have the Cardinals as the much luckier team.
All of which is to say: the Seahawks are a considerably better football team. The identical records heading into Thursday Night Football has a lot more to do with outside circumstances than overall quality, which is the only reason Seattle isn’t favored more tonight.
The Seahawks opened as slight underdogs before being bet down to 1.5-point favorites, but it wouldn’t shock me if that line continues to move that direction.
BetMGM has the best line (-105 at the time of writing), but keep your eyes open for any further movement.
Pick: Seahawks -1.5 (-105)
Seahawks vs Cardinals Over/Under Prediction
I confidently backed the under in an NFC West matchup involving the Cardinals last Sunday, and I don’t see much difference in this matchup with the Seahawks.
Defenses usually have the advantage on a short week, which only helps an under in a game I expect to be played at a slow pace.
Arizona is the slowest-paced team in the NFL this season, running a play every 33 seconds. Furthermore, the Cardinals have no explosive element to their offense as Kyler Murray and Marvin Harrison Jr. cannot get on the same page. Murray’s average depth of target is the second-lowest in the league this season out of all quarterbacks with significant playing time.
The Seattle defense is fifth in total DVOA and is third best in pass rush win rate, according to ESPN data. The Seahawks have allowed just 1.3 points per drive — the best mark in the NFL.
I have a difficult time seeing Arizona improving greatly on its 4.1 yards per play mark from a week ago when they faced another legitimate defense in the 49ers.
The Seahawks want to control the pace of the game as well, but they do it by executing a ground-based attack. The Seattle offensive staff calls running plays at the second-highest rate in the league during neutral game scripts.
However, it will not be an easy task establishing the line of scrimmage versus Arizona's front seven. The Cardinals have the fourth-best mark in terms of adjusted line yards per rush, and opposing running backs have averaged just 3.8 yards per carry against them.
This matchup is shaping up to be yet another under in a game played at night — an angle that has translated to a positive return on investment in six of the last seven seasons when including the beginning of the 2025 regular season.
Pick: Under 43.5
Seahawks vs Cardinals Props
By Chris Prince
Benson is set up for a huge jump in touches with the unfortunate season-ending injury to James Conner, and this number feels a bit light to me. Benson has flashed big play ability multiple times already this season, and is averaging a robust 6 yards per carry through the first 3 weeks of the season.
We have a close 1.5-point spread here, so this game should stay competitive, providing plenty of opportunity for Benson on the ground. Seattle has allowed an average of 80 rushing yards per game to opposing running backs, which includes a couple of games in which their opponent was playing from behind and not attacking with the run as often. In their only "competitive" game, they surrendered 119 rushing yards in week 1 to the Niners and they ranked in the bottom half of the league in rushing yards allowed to running backs in 2024.
Rotogrinders has Benson projected for 69 rushing yards this week and I am aligned with that number, give me the over here.
Pick: Trey Benson Over 55.5 Rushing Yards (-105); bet to 58.5
