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Diamondbacks vs. Cardinals Odds & Betting Predictions - June 22, 2026

Diamondbacks at Cardinals

11:45 pm • ARID

Arizona Diamondbacks

0-0
2
2 - 3

St. Louis Cardinals

0-0
3
Starting Pitchers
pitcherteameraw-l
Andre Pallante logoA.PallanteSt. Louis Cardinals logo3.8312-9
Merrill Kelly logoM.KellyArizona Diamondbacks logo4.9410-14

Diamondbacks at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Diamondbacks
0-0
+1.5
+1.5-163
o8.5-113
+126
Cardinals
0-0
u8.5
-1.5+137
u8.5-106
-151
location pinMonday 11:45 p.m.
June 22, 2026
Busch StadiumSt. Louis
Diamondbacks vs. Cardinals Expert Picks
Matt Trollo
Matt Trollo
Last 30d: 23-20-3 (+6.2u)
STL -145 (F5)
1u
(B365) Kelly 4.47 Bot ERA (only est. < 5) - 7.50 xERA range, Pallante 3.64 dERA - 4.37 Bot ERA. STL 119 proj LU (6 BRR) wRC+ v RHP/L30 days, ARI 88/90. Defenses both great. ARI pen estimators 1/2 run worse L30 days, but BARTOLO rates them better than STL, so F5. Also 0.5u on STL o4.5 (-104 FD) (not available to track yet)
STL o4.5-104
0.52u
(FD) See notes on STL F5
Picks Office
Picks Office
Last 30d: 0-0-0 (+0.0u)
STL -145
0.69u
Sandy Plashkes
Sandy Plashkes
Last 30d: 101-105-4 (+12.2u)
STL -140
1u
Kyle Murray
Kyle Murray
Last 30d: 151-135-9 (+20.4u)
ARI +133
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 72-43-0 (+15.5u)
STL -142
0.35u
RoyalsProps
RoyalsProps
Last 30d: 33-43-2 (-15.7u)
L.Nootbaar o1.5 Hits + Runs + RBIs-105
1.05u
Frank Ammirante
Frank Ammirante
Last 30d: 99-90-0 (-4.3u)
A.Pallante o17.5 Outs-120
1u
Player Prop Savant
Player Prop Savant
Last 30d: 87-77-0 (+9.3u)
STL o4.5-104
1.04u
💰🦡 Jake
💰🦡 Jake
Last 30d: 88-105-1 (+12.1u)
STL -0.5 (F5)-105
2u
Alex Hinton
Alex Hinton
Last 30d: 90-100-1 (-6.0u)
A.Burleson o1.5 Total Bases+105
1u

Diamondbacks vs. Cardinals Previews & Analysis

  • Grant's 5 Home Run Picks for Monday article feature image

    Grant's 5 Home Run Picks for Monday

    Grant Neiffer•
    Jun 22, 2026 UTC
  • 3 MLB Player Props for Monday article feature image

    3 MLB Player Props for Monday

    Alex Hinton•
    Jun 22, 2026 UTC
  • Diamondbacks vs. Cardinals: The Team Total to Bet article feature image

    Diamondbacks vs. Cardinals: The Team Total to Bet

    Action Network Staff•
    Jun 22, 2026 UTC
  • Our 5 MLB Best Bets for Monday article feature image

    Our 5 MLB Best Bets for Monday

    Action Network Staff•
    Jun 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Diamondbacks vs. Cardinals Public Betting Percentages

Away Logo

Diamondbacks

Public

Home Logo

Cardinals

27%

Bets%

73%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cardinals are 1-4 in their last 5 games.
  • Cardinals are 3-2 in their last 5 games against the spread
  • Cardinals are 45-36 in their road games against the spread
  • The totals have gone OVER in 2 of Cardinals' last 5 games
  • The totals have gone OVER in 36 of Cardinals' 81 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		86-7641-4045-3617-3468-40
Diamondbacks		84-7844-3740-4134-4148-37

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		74-82-636-42-338-40-324-26-148-55-5
Diamondbacks		71-87-436-43-235-44-233-40-236-47-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		77-8538-4339-4225-2651-57
Diamondbacks		86-7645-3641-4043-3241-44

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 21st@KCW 12-10-1.5 WO 9STL -127
Jun 20th@KCL 5-6-1.5 LO 9.5KC -120
Jun 18th@KCL 6-14-1.5 LO 9KC -105
Jun 17thSDL 1-6-1.5 LU 10.5SD -122
Jun 16thSDW 3-2-1.5 LU 8STL -116

Diamondbacks vs. Cardinals Injury Updates

Diamondbacks Injuries

  • Blake Walston
    P

    Walston is out with elbow

    Out

  • Cristian Mena
    P

    Mena is doubtful with shoulder

    Doubtful

Cardinals Injuries

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    Diamondbacks vs. Cardinals Box Score
    Diamondbacks Player Stats
    Projected
    PITCHERPCIPKER
    Merrill Kelly logoRM.Kelly, P96623
    Taylor Clarke logoRT.Clarke, P271.220
    Jonathan Loaisiga logoRJ.Loaisiga, P40.100
    HITTERSH-ABRHRRBI
    Ketel Marte logo1K.Marte, 2B2-4000
    Geraldo Perdomo logo2G.Perdomo, SS0-4000
    Corbin Carroll logo3C.Carroll, RF2-4100
    Pavin Smith logo4P.Smith, 1B0-3000
    Ildemaro Vargas logo4I.Vargas, PH0-1000
    Ildemaro Vargas logo4I.Vargas, 1B0-1000
    Nolan Arenado logo5N.Arenado, 3B1-4001
    Adrian Del Castillo logo6A.Del Castillo, C1-4000
    Lourdes Gurriel logo7L.Gurriel, DH0-3000
    Tommy Troy logo8T.Troy, LF1-4111
    Tim Tawa logo9T.Tawa, CF1-3000
    Cardinals Player Stats
    Projected
    PITCHERPCIPKER
    Andre Pallante logoRA.Pallante, P85621
    Ryne Stanek logoRR.Stanek, P110.201
    JoJo Romero logoLJ.Romero, P9100
    George Soriano logoRG.Soriano, P50.100
    Riley O'Brien logoRR.O'Brien, P17100
    HITTERSH-ABRHRRBI
    JJ Wetherholt logo1J.Wetherholt, 2B2-4000
    Ivan Herrera logo2I.Herrera, C1-3000
    Alec Burleson logo3A.Burleson, 1B1-2001
    Jordan Walker logo4J.Walker, RF0-4000
    Lars Nootbaar logo5L.Nootbaar, LF0-2100
    Masyn Winn logo6M.Winn, SS1-4100
    Jimmy Crooks logo7J.Crooks, DH0-3000
    Blaze Jordan logo8B.Jordan, 3B0-2001
    Nathan Church logo9N.Church, CF2-3101

    Diamondbacks vs. Cardinals Odds Comparison

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    Diamondbacks at Cardinals Team Totals

    MatchupOverUnder
    Diamondbacks
    0-0
    N/A
    N/A
    Cardinals
    0-0
    N/A
    N/A