Diamondbacks vs. Cardinals Odds & Betting Predictions - June 22, 2026

Diamondbacks at Cardinals

11:45 pm • ARID
2 - 3
Starting Pitchers
pitcherteameraw-l
Andre Pallante logoA.PallanteSt. Louis Cardinals logo3.5712-6
Merrill Kelly logoM.KellyArizona Diamondbacks logo5.378-11

Diamondbacks at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Diamondbacks
69-62
+1.5
+1.5-163
o8.5-113
+126
Cardinals
66-66
u8.5
-1.5+137
u8.5-106
-151
location pinMonday 11:45 p.m.
June 22, 2026
Busch StadiumSt. Louis
Diamondbacks vs. Cardinals Expert Picks
Picks Office
Picks Office
Last 30d: 23-18-0 (+1.3u)
STL -145
0.69u
Kyle Murray
Kyle Murray
Last 30d: 36-45-2 (-2.6u)
ARI +133
1u
Player Prop Savant
Player Prop Savant
Last 30d: 82-70-1 (+12.3u)
STL o4.5-104
1.04u
Austin Pendergrass
Austin Pendergrass
Last 30d: 33-25-1 (+5.5u)
STL -142
0.35u
💰🦡 Jake
💰🦡 Jake
Last 30d: 34-66-2 (-13.1u)
STL -0.5 (F5)-105
2u
Alex Hinton
Alex Hinton
Last 30d: 40-50-1 (-10.9u)
A.Burleson o1.5 Total Bases+105
1u
Frank Ammirante
Frank Ammirante
Last 30d: 408-427-13 (-12.7u)
A.Pallante o17.5 Outs-120
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 45-82-0 (-39.8u)
STL -140
1u
RoyalsProps
RoyalsProps
Last 30d: 0-0-0 (+0.0u)
L.Nootbaar o1.5 Hits + Runs + RBIs-105
1.05u
Matt Trollo
Matt Trollo
Last 30d: 59-71-5 (-11.3u)
STL o4.5-104
0.52u
(FD) See notes on STL F5
STL -145 (F5)
1u
(B365) Kelly 4.47 Bot ERA (only est. < 5) - 7.50 xERA range, Pallante 3.64 dERA - 4.37 Bot ERA. STL 119 proj LU (6 BRR) wRC+ v RHP/L30 days, ARI 88/90. Defenses both great. ARI pen estimators 1/2 run worse L30 days, but BARTOLO rates them better than STL, so F5. Also 0.5u on STL o4.5 (-104 FD) (not available to track yet)

Diamondbacks vs. Cardinals Previews & Analysis

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Prop Odds Comparison

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Line Movement Tracker

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Diamondbacks vs. Cardinals Public Betting Percentages

Away Logo

Diamondbacks

Public

27%

Bets%

73%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals
70-6233-3337-2914-2556-36
Diamondbacks
70-6137-2933-3226-3043-31

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals
55-71-626-37-329-34-315-23-139-48-5
Diamondbacks
57-70-428-36-229-34-224-30-232-40-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals
66-6632-3434-3221-1845-47
Diamondbacks
69-6238-2831-3433-2335-39

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 21st@KCW 12-10-1.5 WO 9STL -127
Jun 20th@KCL 5-6-1.5 LO 9.5KC -120
Jun 18th@KCL 6-14-1.5 LO 9KC -105
Jun 17thSDL 1-6-1.5 LU 10.5SD -122
Jun 16thSDW 3-2-1.5 LU 8STL -116

Diamondbacks vs. Cardinals Injury Updates

Diamondbacks Injuries

  • Corbin Burnes
    SP

    Burnes is out with elbow

    Out

  • Blake Walston
    SP

    Walston is out with elbow

    Out

  • Cristian Mena
    SP

    Mena is doubtful with shoulder

    Doubtful

Cardinals Injuries

    Diamondbacks vs. Cardinals Box Score
    Diamondbacks Player Stats
    Projected
    PITCHERPCIPKER
    Merrill Kelly logoRM.Kelly, P96623
    Taylor Clarke logoRT.Clarke, P271.220
    Jonathan Loaisiga logoRJ.Loaisiga, P40.100
    HITTERSH-ABRHRRBI
    Ketel Marte logo1K.Marte, 2B2-4000
    Geraldo Perdomo logo2G.Perdomo, SS0-4000
    Corbin Carroll logo3C.Carroll, RF2-4100
    Pavin Smith logo4P.Smith, 1B0-3000
    Ildemaro Vargas logo4I.Vargas, PH0-1000
    Ildemaro Vargas logo4I.Vargas, 1B0-1000
    Nolan Arenado logo5N.Arenado, 3B1-4001
    Adrian Del Castillo logo6A.Del Castillo, C1-4000
    Lourdes Gurriel logo7L.Gurriel, DH0-3000
    Tommy Troy logo8T.Troy, LF1-4111
    Tim Tawa logo9T.Tawa, CF1-3000
    Cardinals Player Stats
    Projected
    PITCHERPCIPKER
    Andre Pallante logoRA.Pallante, P85621
    Ryne Stanek logoRR.Stanek, P110.201
    JoJo Romero logoLJ.Romero, P9100
    George Soriano logoRG.Soriano, P50.100
    Riley O'Brien logoRR.O'Brien, P17100
    HITTERSH-ABRHRRBI
    JJ Wetherholt logo1J.Wetherholt, 2B2-4000
    Ivan Herrera logo2I.Herrera, C1-3000
    Alec Burleson logo3A.Burleson, 1B1-2001
    Jordan Walker logo4J.Walker, RF0-4000
    Lars Nootbaar logo5L.Nootbaar, LF0-2100
    Masyn Winn logo6M.Winn, SS1-4100
    Jimmy Crooks logo7J.Crooks, DH0-3000
    Blaze Jordan logo8B.Jordan, 3B0-2001
    Nathan Church logo9N.Church, CF2-3101

    Diamondbacks vs. Cardinals Odds Comparison

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    Diamondbacks at Cardinals Team Totals

    MatchupOverUnder
    Diamondbacks
    69-62
    N/A
    N/A
    Cardinals
    66-66
    N/A
    N/A