The St. Louis Cardinals host the Arizona Diamondbacks on Monday, June 22. First pitch from Busch Stadium is scheduled for 7:45 p.m. ET. The game will be broadcast on ARID and MLB.TV.
The Cardinals enter as a favorite of -142 on the moneyline and are favored by -1.5 (+146) on the run line. The Diamondbacks, meanwhile, are +120 on the moneyline and +1.5 (-178) on the run line. The over/under sits at 8.5 runs.
Find my MLB picks and Diamondbacks vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
- Diamondbacks vs Cardinals Pick: Cardinals Team Total Over 4.5 (+100)
My Diamondbacks vs Cardinals best bet is on St. Louis to go over its team total. Make sure to find the best odds by checking our live MLB odds page.
Diamondbacks vs Cardinals Odds
| Diamondbacks Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -178 | 8.5 -114o / -106u | +120 |
| Cardinals Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +146 | 8.5 -114o / -106u | -142 |
- Diamondbacks vs Cardinals Moneyline: Diamondbacks +120, Cardinals -142
- Diamondbacks vs Cardinals Over/Under: 8.5 (-114o / -106u)
- Diamondbacks vs Cardinals Run Line: Cardinals -1.5 (+146), Diamondbacks +1.5 (-178)

Diamondbacks vs Cardinals Pick, Betting Analysis
Diamondbacks starting pitcher Merrill Kelly is completely cooked, with a strikeout rate down to 13.6% this season and an absurd 15.2% barrel rate allowed.
He has been particularly dreadful against lefties, allowing a .438 xwOBA and tons of power.
The Arizona bullpen also has just two lefties, and one of them may be unavailable tonight, while nearly all of the Cardinals' best hitters are left-handed.
St. Louis has gone over this number in three straight games, and that includes a 12-run outburst against the Royals yesterday.
This is essentially a nightmare scenario for Kelly, and I expect the Cardinals to make him pay on Monday night. I'm taking the Cardinals to go over their team total.
Pick: Cardinals Team Total Over 4.5 (+100)
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