Astros vs Angels Prediction, Pick, Odds for Sunday, June 22

Astros vs Angels Prediction, Pick, Odds for Sunday, June 22 article feature image
Credit:

Kiyoshi Mio-Imagn Images

Pictured: Mike Trout

The Los Angeles Angels host the Houston Astros on June 22, 2025. First pitch from Angel Stadium is scheduled for 4:07 p.m. EDT; the game will be broadcast on FDSW.

Find my MLB betting preview and Astros vs Angels prediction below, as well as probable pitchers, betting trends, injury reports, and more.

Quickslip

Header First Logo
Header Second Logo

My Astros vs Angels Prediction

  • Astros vs Angels picks: Under 9

My Astros vs Angels best bet is Under 9. Make sure to find the best odds by checking our live MLB odds page.


Astros vs Angels Odds

Astros Logo
Sunday, Jun 22
4:07 p.m. ET
FDSW
Angels Logo
Astros Odds
SpreadTotalMoneyline
-1.5
+135
9
-115o / -105u
-120
Angels Odds
SpreadTotalMoneyline
+1.5
-165
9
-115o / -105u
+100
Odds via BetMGM. Get up-to-the-minute MLB odds here.
BetMGM Logo

Astros vs Angels Projected Starting Pitchers

Ryan Gusto (HOU)StatKyle Hendricks (LAA)
4-3W-L5-6
0.8fWAR (FanGraphs)0.7
4.31/3.96ERA /xERA4.79/3.91
3.91/4.15FIP / xFIP4.73/4.76
1.53WHIP1.29
15K-BB%9.5
39.1GB%39.7
101Stuff+82
99Location+110

Astros vs Angels Prediction, Betting Analysis

This MLB betting system targets Sunday games where the home team is coming off one or two straight overs, indicating recent offensive success or inflated totals. Sundays often mark the final game of a series, typically with early start times following a Saturday night game. These conditions lead to lineup changes, rest days for key hitters, and reduced offensive output as teams manage fatigue late in the week.

Pitchers may also gain an edge, having already faced parts of the opposing lineup earlier in the series. With opening totals between 8 and 9.5 runs, there’s room for value when scoring regression is likely. Historically, betting the under in these specific Sunday setups has delivered consistent returns, taking advantage of a subtle edge the public often overlooks.


Pick: Under 9


Moneyline

There is no play on the moneyline.


Run Line (Spread)

There is no play on the run line.


Over/Under

Take the under in today's Astros vs. Angels matchup.


Astros vs Angels Betting Trends


Astros vs Angels Weather


Get the latest coverage on MLB Weather.
About the Author
Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

Follow Action Network Staff @ActionNetworkHQ on Twitter/X.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.