The St. Louis Cardinals host the Athletics on September 3, 2025. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT; the game will be broadcast on FDSMW.
Find my MLB betting preview and Athletics vs Cardinals prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Athletics vs Cardinals Prediction
- Athletics vs Cardinals pick: Athletics F5 Over 2.5
My Athletics vs Cardinals best bet is on Athletics to record the over total runs in the first five innings. Make sure to find the best odds by checking our live MLB odds page.
Athletics vs Cardinals Odds
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 8.5 -115o / -105u | -110 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -175 | 8.5 -115o / -105u | -110 |
Athletics vs Cardinals Projected Starting Pitchers
| LHP Jeffrey Springs (ATH) | Stat | LHP Matthew Liberatore (STL) |
|---|---|---|
| 10-9 | W-L | 6-11 |
| 1.3 | fWAR (FanGraphs) | 1.6 |
| 4.17/4.21 | ERA /xERA | 4.32/4.72 |
| 4.77/4.63 | FIP / xFIP | 4.03/4.32 |
| 1.19 | WHIP | 1.32 |
| 11.8% | K-BB% | 12.1% |
| 31.6% | GB% | 39.3% |
| 88 | Stuff+ | 93 |
| 96 | Location+ | 99 |
Charlie Wright’s Athletics vs Cardinals Prediction, Betting Analysis
Matthew Liberatore is limping to the finish line. He's now 45.1 IP beyond his workload from 2024. Liberatore hasn't thrown 100+ innings in a season since 2022, and that was mostly at Triple-A. His production tailed off right around that threshold this season.
Liberatore has a 5.77 ERA that is supported by a 5.43 xFIP and 5.42 SIERA in 9 starts since the beginning of July. His strikeout rate has fallen to 14.2% in that span. Liberatore has allowed 3+ runs in 5 straight outings.
The Athletics have been one of the most dangerous lineups in the league against LHP lately. They rank 1st in OPS and wOBA since the start of July and are tied for 1st in wRC+.
Tonight's projected lineup has a massive .228 ISO and a .382 wOBA across 455 plate appearances against LHP this season.
I'm taking the team total in the first 5 innings instead of Liberatore's earned runs prop because the price is more favorable and we get the benefit of unearned runs. Plus, the time frame of both bets should be the same.
Liberatore hasn't gone more than 5 IP since June, so he's unlikely to work into the 6th inning. If you don't have this bet available, the earned runs prop is a fine option.
Pick: Athletics F5 Over 2.5 (+115, Fanatics)
Athletics vs Cardinals Betting Trends
