The Chicago White Sox host the Baltimore Orioles on September 16, 2025. First pitch from Rate Field is scheduled for 7:40 p.m. EDT; the game will be broadcast on CHSN.
Find my MLB betting preview and Orioles vs White Sox prediction below, as well as probable pitchers, betting trends, injury reports and more.
Our Orioles vs White Sox Prediction
- Orioles vs White Sox pick: F5 Under 4
Our Orioles vs White Sox best bet is on the under total runs in the first five innings. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs White Sox Odds
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -205 | 8 100o / -120u | -105 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +175 | 8 100o / -120u | -115 |
Orioles vs White Sox Projected Starting Pitchers
| RHP Dean Kremer (BAL) | Stat | RHP Shane Smith (CHW) |
|---|---|---|
| 9-10 | W-L | 6-7 |
| 2.4 | fWAR (FanGraphs) | 1.6 |
| 4.43/4.04 | ERA /xERA | 3.78/4.26 |
| 4.00/4.18 | FIP / xFIP | 4.36/4.46 |
| 1.26 | WHIP | 1.18 |
| 13.8% | K-BB% | 12.5% |
| 40.5% | GB% | 40.2% |
| 95 | Stuff+ | 95 |
| 101 | Location+ | 98 |
Orioles vs White Sox Prediction, Betting Analysis
This is Game 2 of the series after Baltimore took the opener 4-1 on Monday night behind Colton Cowser’s three-run blast and five steady innings from Kyle Bradish. The win extended Chicago’s skid to four games.
For Tuesday, the Orioles turn to Dean Kremer, who makes his first start since exiting early on September 5 with forearm discomfort. On the other side, the White Sox counter with Shane Smith, who has been a bright spot in an otherwise rough season. Since returning from the injured list on August 1, Smith is 3-0 with a 2.84 ERA across eight starts.
The angle here comes from Evan Abrams’ “Low Total Unders with Line Movement (F5)” system. This model zeroes in on early-game spots where oddsmakers and sharp bettors expect limited scoring.
The key ingredients are all here: a low opening total, downward movement in the full-game line, and a first five innings number that still sits within value range. Modest wind conditions also help suppress offense without inflating prices.
Pick: F5 Under 5 (+105, bet365)
Orioles vs White Sox Betting Trends
