The Cleveland Guardians host the Chicago White Sox on September 12, 2025. First pitch from Progressive Field is scheduled for 7:10 p.m. EDT; the game will be broadcast on CLEG.
Find my MLB betting preview and White Sox vs Guardians prediction below, as well as probable pitchers, betting trends, injury reports and more.
My White Sox vs Guardians Prediction
- White Sox vs Guardians pick: Under 8
My White Sox vs Guardians best bet is on the under total runs. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Guardians Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -160 | 9 +100o / -120u | +145 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +135 | 9 +100o / -120u | -175 |
White Sox vs Guardians Projected Starting Pitchers
| LHP Martin Perez (CHW) | Stat | RHP Tanner Bibee (CLE) |
|---|---|---|
| 1-4 | W-L | 9-11 |
| 0.9 | fWAR (FanGraphs) | 1.1 |
| 3.15/5.31 | ERA /xERA | 4.69/3.83 |
| 3.89/4.90 | FIP / xFIP | 4.69/4.39 |
| 1.07 | WHIP | 1.30 |
| 11.3% | K-BB% | 13.0% |
| 34.9% | GB% | 44.0% |
| 81 | Stuff+ | 102 |
| 101 | Location+ | 98 |
White Sox vs Guardians Prediction, Betting Analysis
The Cleveland Guardians open a new series tonight against the Chicago White Sox as a -175 favorite on the moneyline, while Chicago sits at +145 to pull off the upset. Oddsmakers have set the over/under at 8 runs.
This is Game 1 of the set, with Cleveland entering second in the AL Central at 75-71, while Chicago remains stuck at the bottom with a 57-90 record.
The pitching matchup features veteran left-hander Martin Perez for the White Sox, making his 67th career appearance (56th start) against an AL Central opponent, while Tanner Bibee takes the mound for the Guardians.
While Cleveland is the clear favorite, the better angle comes on the total—specifically the Under 7.5.
This matchup fits Evan Abrams’ “Nighttime Unders with Wind and Recency Bias” system, which targets evening games where recent scoring slightly inflates perception, public interest in the over is limited, and environmental factors (moderate temps, neutral wind) lean toward lower output.
Pick: Under 8 (-120, BetMGM)
White Sox vs Guardians Betting Trends
