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Reds vs Mariners Prediction, Pick, MLB Odds for Wednesday, July 22

Reds vs Mariners Prediction, Pick, MLB Odds for Wednesday, July 22 article feature image
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Joe Nicholson-Imagn Images. Pictured: Mariners SP Emerson Hancock

The Seattle Mariners host the Cincinnati Reds on July 22, 2026. First pitch from T-Mobile Park is scheduled for 3:40 p.m. ET. The game will be broadcast on SEAM.

The Mariners are favored by -148 on the moneyline and by -1.5 on the run line. The Reds are +123 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and Reds vs Mariners prediction below, as well as probable pitchers, weather report, and more.


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Reds vs Mariners Prediction

  • Reds vs Mariners Pick: Mariners ML (-148) / Julio Rodriguez Over 1.5 HRR (-123)

My Reds vs Mariners best bet is on Seattle to win outright and Julio Rodriguez to record two or more hits, runs and runs batted in. Make sure to find the best odds by checking our live MLB odds page.


Reds vs Mariners Odds

Reds Logo
Wednesday, Jul 22
3:40 p.m. ET
SEAM
Mariners Logo
Reds Odds
SpreadTotalMoneyline
+1.5
-174
8
-112o / -108u
+123
Mariners Odds
SpreadTotalMoneyline
-1.5
+143
8
-112o / -108u
-148
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Reds vs Mariners moneyline: Reds +123, Mariners -148
  • Reds vs Mariners over/under: 8 (-112o / -108u)
  • Reds vs Mariners spread: Reds +1.5 (-174), Mariners -1.5 (+143)

Reds vs Mariners Probable Pitchers

Brady Singer (RHP, CIN)StatEmerson Hancock (RHP, SEA)
4-9W-L6-4
0.3fWAR (FanGraphs)1.7
4.56 / 5.19ERA / xERA3.17 / 4.33
5.44 / 4.42FIP / xFIP3.66 / 3.78
11.9K-BB%17.7
43.0GB%41.0
.294BABIP.247
92Stuff+100
97Location+106

Reds vs Mariners MLB Betting Preview, Prediction

The Mariners and Reds will square off at T-Mobile Park.

Emerson Hancock will take the mound for the Mariners, while the visiting Reds will start righty Brady Singer.

While Singer is currently posting a 4.56 ERA on the season with a 1.41 WHIP, Hancock is having himself a phenomenal campaign, recording a 3.17 ERA, along with a remarkably efficient 1.01 WHIP.

In addition to Singer’s struggles, he has been previously dominated by several Mariners over the last couple of seasons.

Though many Seattle sluggers set up particularly well with Singer, I like Mariners’ phenom Julio Rodriguez to have a massive day at the plate.

In 12 previous encounters, Rodriguez has had a definitive edge, having recorded four hits off Singer.

Singer’s four-seamer, which happens to be Rodriguez’s favorite pitch to hit, has resulted in opposing hitters having produced a rather substantial .474 xwOBA. That is alarming when having to face a hitter of Rodriguez’s caliber.

Moreover, my two betting angles ahead of Wednesday’s interleague clash will be on both the Mariners moneyline and also for Rodriguez to exceed his 1.5 HRR mark.

Picks:

  • Mariners ML (-148)
  • Julio Rodríguez Over 1.5 HRR (-123)

Reds vs Mariners Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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