The Minnesota Twins host the Cleveland Guardians on May 19, 2025. First pitch from Target Field is scheduled for 7:40 p.m. EDT; the game will be broadcast on CLEG.
Find my MLB betting preview and Guardians vs Twins prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Guardians vs Twins Prediction
- Guardians vs Twins Picks: Under 7.5
My Guardians vs Twins best bet is Under 7.5. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs Twins Odds, Run Line and Total
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 7.5 -110o / -110u | +120 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 7.5 -110o / -110u | -145 |
William Boor’s Guardians vs Twins Prediction and Pick
When wind blows in between 5-25 mph, fly balls lose carry and home run rates drop significantly, which obviously limits scoring. This system taps into that and targets games in which the total is set between 6-11.
Tonight's Guardians vs. Twins matchup falls into those parameters, providing us with a sharp, weather-based angle that exploits the aforementioned environmental factors.
Pick: Under 7.5
Moneyline
I'm going to pass on the Guardians vs. Twins moneyline.
Run Line (Spread)
I don't have a play for the Guardians vs. Twins run line.
Over/Under
I'm betting the Guardians vs. Twins under.
Guardians vs Twins Betting Trends
