The Athletics host the Cleveland Guardians on May 1, 2026. First pitch from Sutter Health Park is scheduled for 9:40 p.m. ET. The game will be broadcast on NBCS-CA.
The Guardians are favored by -115 on the moneyline and priced at +140 to cover the run line. The Athletics are -105 on the moneyline and -165 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Guardians vs Athletics prediction below, as well as probable pitchers, weather report, and more.
Guardians vs Athletics Prediction
- Guardians vs Athletics Pick: Athletics ML -105
My Guardians vs Athletics best bet is Athletics moneyline. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs Athletics Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +136 | 9.5 -105 / -115 | -116 |
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -164 | 9.5 -105 / -115 | -102 |
- Guardians vs Athletics moneyline: Guardians -116, Athletics -102
- Guardians vs Athletics over/under: 9.5 runs
- Guardians vs Athletics spread: -1.5 (+136), +1.5 (-164)
Guardians vs Athletics Probable Pitchers
| Joey Cantillo (CLE) | Stat | J.T. Ginn (ATH) |
|---|---|---|
| 1-1 | W-L | 0-0 |
| 0.5 | fWAR (FanGraphs) | 0.1 |
| 2.97 / 3.87 | ERA / xERA | 3.24 / 3.34 |
| 3.99 / 3.74 | FIP / xFIP | 4.89 / 4.19 |
| 16.8 | K-BB% | 10 |
| 44.2 | GB% | 51.4 |
| .315 | BABIP | .209 |
| 97 | Stuff+ | 98 |
| 90 | Location+ | 105 |
Guardians vs Athletics MLB Betting Preview
Cleveland Guardians Betting Preview: DeLauter Was Major Addition
Chase DeLauter has slugged .485 through his first 29 games and holds a wRC+ of 131, as the Guardians are once again tied for the AL Central lead with a modest record of 16-16.
Those two storylines make this another enjoyable season for Guardians faithful, but unfortunately, their overall upside still seems fairly capped due to the lack of depth in their lineup.
Cleveland ranked 28th in wRC+ in 2025, but once again, it leaned on fundamentally strong baseball to win the division. While DeLauter has been an excellent addition, the overall process remains comparable this season, as the team ranks 23rd in wRC+ and has averaged 3.84 runs scored per game.
The Guardians rank 20th in xSLG and 17th in BB/K ratio. They've struggled versus righties in particular, as they hold a wRC+ of 90 and have the second-lowest hard-hit rate in MLB versus righties thus far.
After pitching to an ERA of 3.21 in his sophomore campaign in 2025, 26-year-old lefty Joey Cantillo has had a promising start to the season. He's pitched to an ERA of 2.97 with an xFIP of 3.74 and has struck out 10.04 batters per nine.
His zone-contact rate is up 6.2% year-over-year, though he's been hard-hit 42.9% of the time. While his stuff doesn't grade out overly well, the sequencing of his four-pitch mix has been a major strength thus far.
Athletics Betting Preview: Is Ginn Healthy Enough?
After a slow start to the season, the Athletics' lineup has started to live up to the hype. Over the last 14 days, they hold a wRC+ of 112. The team has been successful where it counts of late, as it's won three straight series' and now leads the AL West.
Dating back to the start of last season, Sutter Health Park has been the second-most favorable ballpark for run creation, which has meshed well with the Athletics' offensive approach. They hold a wRC+ of 118 at home this season and rank eighth in hard-hit rate.
They also have hit left-handed pitching quite effectively this season, as they hold a wRC+ of 111 versus lefties.
The Athletics hold the fourth-highest xBA in baseball and certainly have room to grow offensively if Lawrence Butler and Brent Rooker are able to find their form offensively the rest of the way.
J.T. Ginn exited his previous start early due to shoulder tightness, but tests came back clean and he threw his regular bullpen session on Wednesday. Ginn has pitched to an ERA of 3.24 across his first 25 innings this season and has allowed hard contact just 32.4% of the time.
The Athletics' relief staff has been rock solid so far this season, as the relievers have pitched to an ERA of 3.98 and rank fourth in strikeout minus walk rate.
Guardians vs Athletics Pick, Betting Analysis
Though Cantillo does appear likely to be a better-than-average starter this season, his high level of play seems to be getting a lot of credit. (The Guardians are priced as favorites in this matchup versus an Athletics side offering much more offensive upside.)
The Athletics have been hot at the plate of late and have been hard on lefties thus far. They should be well situated to continue their strong run production at home.
While Ginn may not be quite at the level of Cantillo, he's a strong starter in his own right and gets a good spot to author another strong start here versus a Guardians side that hasn't managed much hard contact versus righties.
At -105, there's value backing the Athletics to win this matchup.
Pick: Athletics ML -105 (Play to -110)
