The Baltimore Orioles host the Minnesota Twins on March 26, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 3:05 p.m. EDT. The game will be broadcast on MASN.
The Orioles are favored by -134 on the moneyline and by -1.5 on the run line. The Twins are +116 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Twins vs Orioles prediction below, as well as probable pitchers, weather report, and more.
Twins vs Orioles Prediction
- Twins vs Orioles Pick: Twins ML (+110 or Better)
My Twins vs Orioles best bet is on Minnesota to win outright. Make sure to find the best odds by checking our live MLB odds page.
Twins vs Orioles Odds
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -188 | 8.5 -102o / -120u | +116 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8.5 -102o / -120u | -134 |
- Twins vs Orioles spread: Orioles -1.5 (+155), Twins +1.5 (-188)
- Twins vs Orioles over/under: 8.5 (-102 / -120)
- Twins vs Orioles moneyline: Twins +116, Orioles -134
Twins vs Orioles Betting Preview
This game triggered one of our Action PRO Betting Systems, powered by Evan Abrams.
This system identifies early-season road underdogs (games one through nine) when the moneyline is moderately high (+131 to +500).
Early in the year, oddsmakers and the public often overreact to small sample performance or offseason hype, creating pricing inefficiencies.
Underdogs benefit from unpredictability and inconsistent form among favorites.
Twins vs Orioles Pick, Betting Analysis
The Twins are going to sell at the deadline. They are in the middle of an ownership crisis, and this roster isn’t good enough to all-in.
That said, it isn’t the deadline yet. Minnesota still has plenty of talent, from Byron Buxton at the top of the lineup, to Royce Lewis in the middle of the lineup, to Joe Ryan on the mound.
I prefer Ryan to Trevor Rogers. Ryan projects almost a half-run better than Rogers by most projection systems, as he has significantly better stuff (108 Stuff+ rating vs 97).
The Orioles are due for a bounce-back year, but I think the market may be slightly overvaluing them. They only won 75 games last year, and their Pythag win total was just 70-92.
I wouldn’t be the least bit surprised if the Twins pulled off the Opening Day upset behind the better starting pitcher.
Pick: Twins ML (+110 or Better)
