We have a full 15-game slate today, starting early with Orioles vs. Yankees at 1:05 p.m. ET and closing with Giants vs. Dodgers at 10:10 p.m. ET.
Our experts have analyzed the matchups and found great options for Wednesday.
Below are five expert MLB best bets today.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:05 PM | |
  | 1:10 PM | |
  | 7:40 PM | |
  | 7:40 PM | |
  | 10:10 PM | |
 | All Day | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Alex Hinton's Yankees vs Orioles Best Bet
By Alex Hinton
Since the start of last season, the Yankees are 14-5 against the Orioles. They have won 13 of those games by two runs or more, and they are plus odds on the run line today.
Winning today's game by two or more will also be in the Yankees' best interest. They are just 3-9 in one-run games this season, but 24-7 when winning by two runs or more.
Today's game being moved up may also play to the Yankees' advantage as they are 10-7 in day games this season, while Baltimore is just 9-13 thus far. Both teams just saw the opponent's starting pitcher recently, but if Kyle Bradish continues to struggle, that advantage goes to the Yankees as well.
Max Fried has a 3.52 ERA in six career starts against the Orioles, and he has won two of three starts against them as a Yankee.
If the Yankees get to Bradish again, they should win this game by two or more with Fried on the mound.
Pick: Yankees -1.5 (-110 or Better)
Read Hinton's full Yankees-Orioles preview here:
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Sean Paul's Angels vs Guardians Prediction
By Sean Paul
I see value in Cleveland at anything below -170.
The pitching matchup favors them, even with Reid Detmers likely seeing some positive regression.
I just don't see how the Angels score off of Parker Messick. He could tally a bunch of strikeouts and make this scuffling offense appear foolish.
All it takes is for Cleveland to clog the bases, maybe hit one ball out, and it should cruise to another win.
Pick: Guardians ML (-170 or Better)
Read Paul's full Guardians-Angels preview here:
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Ryan Minion's Royals vs White Sox Player Prop
By Ryan Minion
Noah Schultz has had a very up-and-down start to his first year in the Big Leagues, currently running a 4.68 ERA and 1.32 WHIP. I have faith in his long-term upside because of his 22% strikeout rate and versatile arsenal, but I’m concerned about his control and command of that arsenal.
Kansas City’s lineup is not in the best form either — the Royals have lost three of their past five.
While the lineup has mostly struggled, Bobby Witt Jr. has started to find his rhythm in the batter’s box, and I think he’s got a good matchup against Schultz.
If Schultz fails to establish his four-seam fastball early, he will likely be forced to resort to his off-speed arsenal, which includes a sweeper, sinker, and change-up. And given Schultz's lack of command over his past three outings, I expect the Sox left-hander to face a lot of problems matched up with an elite contact hitter with tremendous patience.
Pick: Bobby Witt Over 1.5 Total Bases (-130 or Better)
Check out all of Minion's best bets in today's edition of The Leadoff:
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John Feltman's Padres vs Brewers Over/Under Pick
By John Feltman
There’s a strong case for the Under 7 tonight in Milwaukee, and the early market movement already tells part of the story. This total opened at 7.5 and was quickly bet down to 7 overnight. That’s not surprising considering the pitching matchup we’re getting with Michael King and Jacob Misiorowski on the mound.
This also feels like one of those games where offense cools down after a higher-scoring game the night before. Both lineups saw much more hittable pitching yesterday. I wouldn’t bat an eye if this ends up being a 1-0 or 2-1 final.
King has quietly developed into one of the best pitchers in the National League. According to Baseball Savant, he continues to rank near the top of baseball in chase rate, whiff rate, and hard-hit suppression. The sweeper has become one of the nastiest pitches in the league, and hitters still struggle to pick him up because everything tunnels so well off the sinker.
What makes King so dangerous is how difficult it is to string together quality contact against him. He limits walks, misses bats in key situations, and rarely allows innings to spiral. Even when teams get traffic on the bases, he has the arsenal to escape without damage. His underlying metrics continue to match the results every time he takes the mound.
On the other side, Misiorowski has some of the best raw stuff in baseball already. The velocity immediately stands out because he’s already touched 103 mph multiple times this season, but the secondary pitches are what have taken him to another level in 2026.
The slider has become a legitimate wipeout pitch, and hitters are producing very little quality contact against him. Misiorowski has been one of the hardest pitchers in baseball to barrel through the first month of the season.
The strikeout numbers have been elite, but the contact profile might be even more impressive. Opposing hitters simply are not squaring him up consistently.
His last outing against the Yankees showed exactly why the ceiling is so high. He struck out 11 hitters across six shutout innings and completely overpowered one of the better offenses in baseball. Once he gets ahead in counts, at-bats become extremely uncomfortable because hitters have to respect triple-digit velocity while also protecting against the slider.
The bullpen matchup only strengthens the under case. Milwaukee entered Wednesday with a bullpen ERA sitting around the mid-3.00s, which ranks among the better marks in baseball early this season. The Brewers have consistently gotten quality late-inning work from Abner Uribe and Trevor Megill, and they’ve done a strong job limiting damage once games get into the middle innings.
San Diego’s bullpen has been even more dominant lately, especially with Mason Miller locking down the backend. Miller has looked completely unhittable through the first month of 2026. The strikeout rate is absurd, the ERA is barely above 1.00, and hitters have struggled to generate any hard contact against him. He’s once again near the top of baseball in fastball velocity and whiff percentage.
That’s what makes this under feel so strong. It’s not just two aces starting the game, but it’s handing the ball off to reliable late-inning arms afterward.
With two dominant starters, elite swing-and-miss stuff on both sides, and strong bullpen support behind them, this feels much more like a 3-2 type of game than a slugfest.
I will definitely be taking the Under 7, but I think it is worth laddering alternate unders as well.
Pick: Under 7 (-110 or Better)
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Derek Carty's Giants vs Dodgers Pitching Prop
By Derek Carty
There may be some value on Robbie Ray's strikeouts prop.
THE BAT X is projecting him to record 4.71 strikeouts, and oddsmakers are implying 5.41.
The model believes there is a 66% chance he records fewer than six strikeouts.
The best value is on Under 5.5 at -118 or better, but this play is still good down to -152.
Pick: Robbie Ray Under 5.5 Strikeouts (-152 or Better)
Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!
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Sean Zerillo's Full Action App Card for Wednesday
Need more picks for Wednesday's action? It's always wise to see what our guy Zerillo is betting on!
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