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MLB Picks, Best Bets, Props, Predictions Today – September 20

MLB Picks, Best Bets, Props, Predictions Today – September 20 article feature image
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We have a 16-game slate on Saturday, thanks to a Guardians-Twins day-night doubleheader, and several of these matchups have massive playoff implications.

So there's a lot of baseball on the schedule today, but we have you covered. Our MLB betting experts and systems have sifted through the latest MLB odds and have made their predictions below.

So, continue reading for today's MLB best bets.

Quickslip

MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Cleveland Guardians LogoMinnesota Twins Logo
2:10 p.m.
New York Yankees LogoBaltimore Orioles Logo
7:05 p.m.
San Diego Padres LogoChicago White Sox Logo
7:10 p.m.
Philadelphia Phillies LogoArizona Diamondbacks Logo
8:10 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Bet Labs' Guardians vs Twins Best Bet: Expect a Low-Scoring Game

Cleveland Guardians Logo
Saturday, September 20
2:10 p.m. ET
MLB.TV
Minnesota Twins Logo
Under 7.5 (-110)
bet365 Logo

By Bet Labs

The "Daytime Unders with Efficient Arms" system bets the under in daytime games where solid visiting arms suppress scoring and the home offense is steady but not explosive, such as the first game of the doubleheader today between the Guardians and Twins. These are the conditions:

  • Day games (11:00–14:59 ET) often play more slowly due to the sun, shadows, and shorter rest.
  • Visitor SP filters (ERA 3–4.76 and WHIP 1.07–1.39) identify efficient pitchers capable of limiting damage without elite notoriety.
  • Home team hit rate between 7.81 and 8.24 ensures average offensive output—enough to avoid “over” volatility but not dominate.
  • Regular-season only avoids erratic postseason scoring.

Combined with lower totals and calm game tempos, this approach isolates a pocket where public expectations may overshoot actual output.

MLB Icon
Evan Abrams / Bet Labs – Daytime Unders with Efficient Arms
the game started between 11:00 and 14:59 ET
the home team's number of hits per game is between 7.81 and 8.24
the visiting team's starting pitcher's ERA is between 3 and 4.76
the visiting team's starting pitcher's WHIP is between 1.07 and 1.39
the game is played during the Regular season
betting on the Under
$1,566
WON
280-247-34
RECORD
53%
WIN%

Pick: Under 7.5 (-110)



Derek Carty's Yankees vs Orioles: Great Odds for Judge

New York Yankees Logo
Saturday, September 20
7:05 p.m. ET
MLB.TV
Baltimore Orioles Logo
Aaron Judge Home Run (+265)
bet365 Logo

By Derek Carty

There may be some value in Aaron Judge's home runs prop. THE BAT X is projecting him to record 0.43 home runs, and oddsmakers are implying 0.32.

The model believes there is a 36% chance he records at least one home run, so there is value on the over at +265.

Love THE BAT X? Get all of Carty’s sports betting projections at EV Analytics!

Pick: Aaron Judge Home Run (+265)



PRO's Padres vs White Sox Best Bet: Fade Darvish's Strikeouts

San Diego Padres Logo
Saturday, September 20
7:10 p.m. ET
MLB.TV
Chicago White Sox Logo
Yu Darvish Under 5.5 Strikeouts (-160)
bet365 Logo

By Action PRO

PRO projects Padres starter Yu Darvish with 4.45 strikeouts today, which represents an excellent 11.5% edge against the market.

The 39-year-old right-hander only struck out five batters in his last outing, and has not recorded more than five Ks in five of his previous eight starts.

With the line at 5.5, you can fade the veteran tonight against the White Sox.

Pick: Yu Darvish Under 5.5 Strikeouts (-160)



Bet Labs's Phillies vs Diamondbacks Best Bet: System Recommends the Over

Philadelphia Phillies Logo
Saturday, September 20
8:10 p.m. ET
MLB.TV
Arizona Diamondbacks Logo
Over 9 (-110)
bet365 Logo

By Bet Labs

Tonight, the Phillies visit Chase Field, home of the Diamondbacks, and our Bet Labs system recommends the over, based on this analysis.

Late in the MLB season, games played in hitter-friendly or high-variance environments — such as in Colorado, Arizona, and Washington — tend to go over the total when the closing line is modest (≤10.5).

These markets often underestimate run production during the final stretch of the season due to weather conditions (e.g., dry heat in AZ/CO, humid air in DC) and expanded rosters increasing bullpen volatility.

Public perception around fatigue or playoff pressure may further depress totals.

This creates value when betting overs in August to October for these specific home teams, particularly during regular-season games.

MLB Icon
Evan Abrams – Late Season Overs, Lower Totals — COL, ARI, WAS Home (YEAR)
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2018 or 2017 or 2016 or 2015 or 2014 season
the game was played in September or August or October
the closing total is between 0 and 10.5
betting on the Over
the game is played during the Regular season
the home team is Washington Nationals or Arizona Diamondbacks or Colorado Rockies
$5,839
WON
352-270-31
RECORD
57%
WIN%

Pick: Over 9 (-110)



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Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

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