Baseball fans are being treated to a full slate of games as the regular season winds down. Multiple games tonight have playoff implications and the betting opportunities are plentiful. Our MLB betting experts have already sifted through the latest MLB odds and made their picks and predictions, so continue reading for today's MLB best bets.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 6:35 p.m. | |
  | 6:40 p.m. | |
  | 6:45 p.m. | |
  | 9:40 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Bet Labs' Rays vs Orioles Best Bet
By Bet Labs
This MLB system is built on the premise that sharp money moving totals downward, paired with weak public support on the under, creates an exploitable edge in the betting market.
The strategy focuses on regular season games from 2019 to 2025 where the closing total lands between 8 and 10 — sweet spots for scoring volatility. It isolates games where the over/under line has dropped significantly from open to close, signaling smart money on the under, yet public sentiment heavily favors the over, with only a small share of bets backing the under. This mismatch between money and ticket count indicates potential value, especially when the difference between those two figures is meaningful, but not extreme. To reduce noise, the system excludes games played in extreme heat or cold, only including those where temperatures range from mild to warm. It also requires both teams to have a recent record of games that hover around the total, suggesting no extreme streaks skewing expectations. These filters ensure that neither team is riding unsustainable over or under trends. Ultimately, this system looks for low-confidence unders that have been steamed down by sharp bettors, where public interest is light and the number still sits within a realistic scoring range. The result is a consistent edge, backed by a high sample size and strong return on investment.
Overall, this system has cashed 59% of its picks (584-402-48) and generated a 14% ROI. This season, the ROI is 13% (166-114-10, 59%).
Pick: Under 9 (-121)
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Tony Sartori's Tigers vs Guardians Best Bet
By Tony Sartori
The Guardians possess a mere .187 expected batting average (xBA), .267 xSLG, and .220 expected weighted on-base average (xwOBA) through 145 combined plate appearances against Tarik Skubal.
With clear hitting and pitching advantages, the Tigers are the team to back in this contest.
The question is whether to take the moneyline or the run line. Considering that each of Detroit’s past 10 wins have come by at least a two-run margin, it’s worth taking a shot on the latter.
Pick: Tigers -1.5 (+121)
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Sean Zerillo's Marlins vs Phillies Best Bet
By Sean Zerillo
Both teams are in their superior split, but I prefer Philadelphia's offense. Over the past 30 days, the Phillies rank third against right-handed pitching with a 127 wRC+, while the Marlins are eighth against lefties (114 wRC+).
I also prefer the Phillies' bullpen. Since the Trade Deadline, Philadelphia ranks 14th in xFIP, eighth in K-BB%, eighth in Pitching+ and 15th in botERA. Meanwhile, Miami ranks 26th, 25th, 13th and 19th, respectively. Season-long defensive metrics prefer Miami (16th DRS, 7th OAA vs. 22nd, 12th for PHI), but my model makes Philadelphia the better defensive club.
I project the Phillies at -256 and would bet them to -233.
Pick: Phillies Moneyline (-215)
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Bet Labs' Dodgers vs Diamondbacks Best Bet
By Bet Labs
Late in the MLB season, games played in hitter-friendly or high-variance environments — such as in Colorado, Arizona, and Washington — tend to go over the total when the closing line is modest (≤10.5). These markets often underestimate run production during the final stretch of the season due to weather conditions (e.g., dry heat in AZ/CO, humid air in DC) and expanded rosters, which increase bullpen volatility. Public perception around fatigue or playoff pressure may further depress totals.
This creates value when betting overs in August to October for these specific home teams, particularly during regular season games.
Overall, this system is 353-271-31 (57%) and has produced a 9% ROI. This season, the system has produced a 4% ROI and has cashed 55% of its picks (28-23-5).
Pick: Over 9 (+100)
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