The regular season is winding down, but we still have a full slate of games on Wednesday, September 24. Our MLB betting experts have dug into the latest MLB odds and identified the best value on the board.
So, continue reading for today's MLB best bets, including props and predictions for several games.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 12:15 p.m. | |
  | 4:10 p.m. | |
  | 8:05 p.m. | |
  | 10:05 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Charlie Disturco's Nationals vs Braves Best Bet: Value-Packed SGP
By Chilly Bets
In a game that doesn’t mean much in the standings, we’re backing the home side to continue their winning streak and end the season on a positive note.
The Braves have won 10 straight games. Despite a season marked by a slow start and injuries that kept them out of playoff contention, this team is playing for pride and looking to finish strong.
We’re also backing Ronald Acuna Jr. to record a hit. He’s hit safely in three straight games and five of his last six, while also homering in three of his past five.
Pick: Braves Moneyline, Ronald Acuna Jr. Hit (-110)
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Sean Zerillo's Brewers vs Padres Best Bet: Brewers Showing Value
By Sean Zerillo
The Brewers have won 19 consecutive games that Quinn Priester has started.
He has comparable metrics (3.64 xERA, 3.81 xFIP, 12.5% K-BB) to Padres starter Dylan Cease (3.48 xERA, 3.65 xFIP), but worse stuff (98 Stuff+ to 108).
The AL West is still within reach for San Diego (1.5 games back), while Milwaukee is holding off Philadelphia for the top overall seed (2.5 game lead). Both teams are continuing to play their top lineups.
While I project William Contreras to miss this game (the Brewers typically sit one of Contreras or Christian Yelich the day after a night game), I still project Brewers moneyline at -104.
The Brewers have significant advantages defensively and on the basepaths. I'd play the Brewers moneyline to +102.
Pick: Brewers Moneyline (+105)
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Bet Labs' Mets vs Cubs Best Bet: System Suggests Under
By Bet Labs
The "Wind Whisper Unders" system is built to target MLB totals where weather and market signals align quietly, but consistently toward the under.
It targets regular season games from 2020 through 2025 where the closing total falls between 7 and 10 runs — a middle range that allows for variance but avoids extremes. This strategy homes in on games with a specific weather profile: wind blowing from left, in from right, or straight in, with speeds between 3-15 mph. Combined with moderate temperatures between 30-70 degrees, these environmental conditions help suppress deep fly balls without overly skewing the market. Line movement also plays a role. The total must have dropped by up to 2.5 runs from open to close, signaling steady downward pressure from sharper bettors. Importantly, the public is not fully behind the under — support remains modest, falling between 1-55%. This indicates market resistance and helps ensure the number isn’t over-adjusted.
By aligning downward line moves, cooling weather patterns, and under-the-radar betting splits, the system consistently identifies games where offense is subtly — but significantly — less likely to break out.
Overall, this system has produced a 14% ROI and cashed 59% (508-346-47) of its picks. This season, it has cashed 56% of its picks (123-95-9) and generated a 7% ROI.
Pick: Under 7 (+100)
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Bet Labs' Astros vs Athletics Best Bet: Scoring May Be Limited
By Bet Labs
This system targets evening games in which public interest on the over is muted, recent home team scoring has run slightly hot, and subtle environmental signals align with lower-scoring outcomes.
Games start between 7:00 and 11:59 p.m. ET, and the market over percentage sits below 50, suggesting minimal public pressure on inflated totals. Meanwhile, the wind direction — whether blowing in, across the field, or neutral — paired with moderate temperatures between 26-74 degrees, introduces natural resistance to run scoring. The home team is competitively priced on the moneyline and has a wide win rate window, providing no clear power imbalance that might inflate totals. When layered together, these filters isolate a soft edge in a game environment where bettors overlook the under due to recency bias and lack of extreme public conviction.
Overall, this system is 1501-1146-143 (57%) with a 10% ROI. This season, the system has generated an 8% ROI and is 63-48-3 (57%).
Pick: Under 9 (-110)
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