The Cincinnati Reds host the Pittsburgh Pirates on April 1, 2026. First pitch from Great American Ball Park is scheduled for 12:40 p.m. EDT. The game will be broadcast on CINR.
The Pirates are favored by -163 on the moneyline and by -1.5 on the run line. The Reds are +137 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Pirates vs Reds prediction below, as well as probable pitchers, weather report, and more.
Pirates vs Reds Prediction
- Pirates vs Reds Pick: Paul Skenes Under 7.5 Strikeouts (-131, DraftKings)
My Pirates vs Reds best bet is on Paul Skenes' strikeout prop. Make sure to find the best odds by checking our live MLB odds page.
Pirates vs Reds Odds
| Pirates Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +102 | 7.5 102o / -122u | -168 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -122 | 7.5 102o / -122u | +139 |
- Pirates vs Reds spread: Pirates -1.5 (+102), Reds +1.5 (-122)
- Pirates vs Reds over/under: 7.5 (-102 / -122)
- Pirates vs Reds moneyline: Pirates -168, Reds +139
Pirates vs Reds MLB Player Prop Pick
Our PRO Prop Projections show value on Paul Skenes' strikeout prop for Wednesday.
His current strikeout prop line is set at 7.5 (-131) over at DraftKings, implying he's due for about 6.9 strikeouts on Wednesday.
However, our PRO tools project him for 6.8 strikeouts against the Reds, providing about a 6% edge against the current price at DraftKings.
We all know that Skenes blew up against the Mets in his first start (5 ER, 4 H, 2 BB, 1 K). While I don't expect a repeat performance, I don't think the young star is quite stretched out yet, especially after only pitching 2/3s of an inning in his 2026 debut. He might be limited on Wednesday.
Additionally, Cincinnati is particularly tough to pitch in, with Great American Ball Park consistently ranking among the top five in park factor.
These factors combined should provide just enough of an edge to keep Skenes under his strikeout prop line for the second consecutive game.
Pick: Paul Skenes Under 7.5 Strikeouts (-131, DraftKings)
