The Chicago White Sox host the St. Louis Cardinals on on June 19, 2025. First pitch from Rate Field is scheduled for 2:10 p.m. ET; the game will be broadcast on FDSMW.
The two teams face off in Game 1 of their doubleheader on Thursday.
Find my MLB betting preview and Cardinals vs White Sox prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Cardinals vs White Sox Prediction
- Cardinals vs White Sox pick: Erick Fedde Under 4.5 Strikeouts (-135)
My Cardinals vs White Sox best bet is on Erick Fedde under 4.5 strikeouts. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs White Sox Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +115 | 8 -115o / -105u | -145 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -140 | 8 -115o / -105u | +120 |
Cardinals vs White Sox Projected Starting Pitchers
| Erick Fedde (STL) | Stat | Sean Burke (CHW) |
|---|---|---|
| 3-6 | W-L | 3-7 |
| 0.8 | fWAR (FanGraphs) | 0.2 |
| 3.65 / 4.98 | ERA /xERA | 4.71 / 5.45 |
| 4.13 / 4.92 | FIP / xFIP | 5.13 / 5.20 |
| 1.28 | WHIP | 1.44 |
| 5.2 | K-BB% | 6.8 |
| 40.2 | GB% | 31.8 |
| 91 | Stuff+ | 92 |
| 105 | Location+ | 99 |
Cardinals vs White Sox Prediction, Betting Analysis
Erick Fedde has had some recent success with strikeouts, but I think this is a good spot to fade him, as the 4.5 number seems to be too high.
This is a matchup against a weak White Sox lineup, but they also have several low-strikeout hitters in the lineup.
Since the start of last season, just three hitters in the projected lineup have a strikeout percentage over 22% against right-handed pitching.
The lineup is also projected to have six lefties in it, and this season, Fedde has a strikeout percentage of just 14.5% against lefties.
Pick: Erick Fedde Under 4.5 Strikeouts (-135)
Moneyline
I don't have a moneyline play for this Cardinals vs. White Sox game.
Run Line (Spread)
I also don't have a play on the run line for this game.
Over/Under
I'm not targeting the regular over/under, but I like Erick Fedde under 4.5 strikeouts at -135.
