The San Diego Padres host the St. Louis Cardinals on May 10, 2026. First pitch from Petco Park is scheduled for 4:10 p.m. EDT. The game will be broadcast on CARD.
The Padres are favored by -136 on the moneyline and by -1.5 on the run line. The Cardinals are +116 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Cardinals vs Padres prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Padres Prediction
- Cardinals vs Padres Pick: Under 8.5
My Cardinals vs Padres best bet is on the Under. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Padres Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -188 | 8.5 -105o / -115u | +116 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8.5 -105o / -115u | -136 |
- Cardinals vs Padres moneyline: Cardinals +116, Padres -136
- Cardinals vs Padres over/under: 8.5 (-105o / -115u)
- Cardinals vs Padres spread: Padres -1.5 (+155), Cardinals +1.5 (-188)
Cardinals vs Padres Probable Pitchers
| Kyle Leahy (RHP, STL) | Stat | Walker Buehler (RHP, SDP) |
|---|---|---|
| 4-3 | W-L | 2-2 |
| -0.1 | fWAR (FanGraphs) | 0.6 |
| 4.93 / 6.00 | ERA / xERA | 5.64 / 4.71 |
| 5.21 / 4.15 | FIP / xFIP | 3.46 / 3.82 |
| 8.8% | K-BB% | 12.4% |
| 50.4% | GB% | 46.8% |
| .345 | BABIP | .348 |
| 89 | Stuff+ | 95 |
| 104 | Location+ | 96 |
Cardinals vs Padres MLB Betting Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
In matchups between winning teams, sportsbooks often inflate totals due to perceived offensive capability, yet these teams also tend to have stronger pitching and tighter late-game execution — leading to a profitable edge on the under.
Pick: Under 8.5
