- The 2022 NCAA Tournament officially gets underway with Tuesday's two First Four matchups.
- Based on our college basketball picks and predictions, tonight's second First Four game, Indiana vs. Wyoming, fits the criteria of a historically-profitable betting system.
- Below we detail which side of Indiana vs. Wyoming matches a college basketball betting system with a 61% against-the-spread win rate dating back to 2010.
Indiana vs. Wyoming Odds
| Indiana Odds | -4 |
| Wyoming Odds | +4 |
| Over/Under | 135.5 |
| Date | Tuesday, March 15 |
| Time | 9:10 p.m. ET |
| Channel | truTV |
*Odds as of Tuesday morning
The NCAA Tournament's First Four matchups tip off Tuesday night, starting with a meeting of No. 16 seeds with Texas A&M-Corpus Christi taking on Texas Southern at 6:40 p.m. ET, followed by No. 12 seeds Indiana and Wyoming facing off at 9:10 p.m. ET.
While our college basketball betting tools have yet to identify much value on these early First Four matchups, there’s a PRO Betting System lighting up Indiana vs. Wyoming — and a good one at that.
So, let's go ahead and take a deeper dive into Indiana vs. Wyoming and lay out the details of this system that has produced a 61% against-the-spread (ATS) win rate dating back to the 2010 NCAA Tournament.
Indiana vs. Wyoming Pick
Based on live NCAA Tournament odds, Indiana is a 4-point favorite over Wyoming and this spread has yet to see much movement since opening.
