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NCAA Tournament Betting System Pick for Indiana vs. Wyoming: Tuesday’s First Four College Basketball Prediction

NCAA Tournament Betting System Pick for Indiana vs. Wyoming: Tuesday’s First Four College Basketball Prediction article feature image
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Photo by David Becker/Getty Images. Pictured: Graham Ike #33 of the Wyoming Cowboys

  • The 2022 NCAA Tournament officially gets underway with Tuesday's two First Four matchups.
  • Based on our college basketball picks and predictions, tonight's second First Four game, Indiana vs. Wyoming, fits the criteria of a historically-profitable betting system.
  • Below we detail which side of Indiana vs. Wyoming matches a college basketball betting system with a 61% against-the-spread win rate dating back to 2010.

Indiana vs. Wyoming Odds

Indiana Odds -4
Wyoming Odds +4
Over/Under 135.5
Date Tuesday, March 15
Time 9:10 p.m. ET
Channel truTV

*Odds as of Tuesday morning

The NCAA Tournament’s First Four matchups tip off Tuesday night, starting with a meeting of No. 16 seeds with Texas A&M-Corpus Christi taking on Texas Southern at 6:40 p.m. ET, followed by No. 12 seeds Indiana and Wyoming facing off at 9:10 p.m. ET.

While our college basketball betting tools have yet to identify much value on these early First Four matchups, there’s a PRO Betting System lighting up Indiana vs. Wyoming — and a good one at that.

So, let’s go ahead and take a deeper dive into Indiana vs. Wyoming and lay out the details of this system that has produced a 61% against-the-spread (ATS) win rate dating back to the 2010 NCAA Tournament.

Indiana vs. Wyoming Pick

Based on live NCAA Tournament odds, Indiana is a 4-point favorite over Wyoming and this spread has yet to see much movement since opening.