NCAA Tournament Betting System Pick for Indiana vs. Wyoming: Tuesday’s First Four College Basketball Prediction

NCAAB

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Photo by David Becker/Getty Images. Pictured: Graham Ike #33 of the Wyoming Cowboys

PJ Walsh

Updated:

Mar 15, 2022, 04:25 PM EDT

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The 2022 NCAA Tournament officially gets underway with Tuesday's two First Four matchups.
Based on our college basketball picks and predictions, tonight's second First Four game, Indiana vs. Wyoming, fits the criteria of a historically-profitable betting system.
Below we detail which side of Indiana vs. Wyoming matches a college basketball betting system with a 61% against-the-spread win rate dating back to 2010.

Indiana vs. Wyoming Odds

Indiana Odds	-4
Wyoming Odds	+4
Over/Under	135.5
Date	Tuesday, March 15
Time	9:10 p.m. ET
Channel	truTV

*Odds as of Tuesday morning

The NCAA Tournament's First Four matchups tip off Tuesday night, starting with a meeting of No. 16 seeds with Texas A&M-Corpus Christi taking on Texas Southern at 6:40 p.m. ET, followed by No. 12 seeds Indiana and Wyoming facing off at 9:10 p.m. ET.

While our college basketball betting tools have yet to identify much value on these early First Four matchups, there’s a PRO Betting System lighting up Indiana vs. Wyoming — and a good one at that.

So, let's go ahead and take a deeper dive into Indiana vs. Wyoming and lay out the details of this system that has produced a 61% against-the-spread (ATS) win rate dating back to the 2010 NCAA Tournament.