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Louisville vs. Duke Betting Odds, Picks, Predictions: Can Blue Devils Bounce Back After Shocking Loss?


Photo by Rich von Biberstein/Icon Sportswire via Getty Images. Pictured: Mike Krzyzewski speaks with Cassius Stanley (2)

  • Duke is an 8-point betting favorite over Louisville in the latest odds for Saturday's top 15 ACC matchup.
  • The Blue Devils are coming off a shocking loss to Clemson in which they were an 11-point favorite, but should return to Cameron Indoor Stadium with a renewed defensive focus.
  • Get our experts' Duke vs. Louisville picks below.

Louisville vs. Duke Odds

  • Odds: Duke -8
  • Total: 138.5
  • Time: 6 p.m. ET
  • TV: ESPN
  • Location: Durham, N.C.

Odds as of Saturday morning and via BetMGM, where Action Network users get a risk-free bet up to $500.

Duke’s shocking loss to Clemson earlier this week takes a little shine off this matchup. But it’s a huge ACC tilt nonetheless.

Louisville will be looking to win just its second Quad 1 game of the season when it goes to Cameron Indoor on Saturday night in primetime.

The Cardinals have bounced back after two straight losses over New Year’s and taken care of business in their last three.

Can they cover the big spread tonight?

How Duke-Louisville Odds Have Moved

The market has moved in Duke’s favor to -8 at most books after opening -7. The Blue Devils are getting 65% of the money in this matchup.

With 66% of the bets and 81% of the money on the over, it’s gone up from 136 to 137.5. — Steve Petrella


When Duke Has the Ball

The Cardinals play stellar defense, 18th in the country in defensive efficiency and 11th in opponent 2-point percentage.

The issue is defending the glass, as Duke is No. 6 in the nation in offensive rebounding. That is a big advantage over a Louisville defense that is averaging just 26.4 rebounds per game for a rank of 97th.

Louisville may be incapable of forcing takeaways, as well. The Cardinals are 316th in defensive steal percentage, an area Duke could be taken advantage of by a team in the future. — Collin Wilson

When Louisville Has the Ball

Experience is certainly on the Louisville side, as Jordan Nwora and Steven Enoch lead a roster that is familiar with Duke. Last season, the Cardinals suffered a 2-point loss to Duke after leading late into the game.

Louisville must stay hot from beyond the arc, shooting 40% or better the past four games with a conference percentage of 44%, but that number is unsustainable in the long run.

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