Clemson vs. Louisville Odds & Betting Predictions - November 15, 2025

Clemson at Louisville

12:30 am • ESPN

Clemson Tigers

@

Louisville Cardinals

MatchupOpenSpreadTotalMoneyline
Clemson 4-5	-6.5	+3-110	o50.5-112	+130
Louisville 7-2	u60.5	-3-110	u50.5-108	-155

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Saturday 12:30 a.m.

November 15, 2025

L&N Federal Credit Union StadiumLouisville

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57°Fahrenheit

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0%Rain

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4Wind

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NCAAF Public Betting

Louisville are 4-1 in their last 5 games.
Louisville are 1-4 in their last 5 games against the spread
Louisville are 3-0 in their road games against the spread
The totals have gone OVER in 3 of Louisville' last 5 games
The totals have gone OVER in 4 of Louisville' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Louisville	3-6	0-6	3-0	2-6	1-0
Clemson	3-6	1-5	2-1	3-6	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Louisville	5-4	4-2	1-2	5-3	0-1
Clemson	4-5	3-3	1-2	4-5	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Louisville	7-2	N/A	N/A	6-2	1-0
Clemson	4-5	N/A	N/A	4-5	N/A

date	opponent	score	spread	over/under	moneyline
Nov 9th	CAL	L 26-29	-18.5 L	O 48.5	CAL -1100
Nov 1st	@VT	W 28-16	-10.5 W	U 52.5	LOU -395
Oct 25th	BC	W 38-24	-25.5 L	O 54.5	LOU -2800
Oct 17th	@MIA	W 24-21	+10.5 W	U 49.5	LOU +340
Oct 4th	UVA	L 27-30	-6.5 L	U 60	UVA -245

Total

Passing

2596

YDS

2219

218/326

Comps/Atts

206/324

7.96

YPA

6.85

18/6

TDs/INTs

12/8

14/86

Sacks/Yards

18/138

Rushing

1088

Rush Yards

1394

284

Attempts

276

3.83

YPC

5.05

13

TDs

20

Turnovers

Fumbles Lost

6

Interceptions

8

Efficiency

24/28 85.7%

Redzone

25/28 89.3%

43/118 0%

3rd Down

49/123 0%

16/26 0%

4th Down

4/8 0%

First Downs

191

Total

181

114

Pass

97

64

Rush

68

13

Penalty

16

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Clemson 4-5	N/A	N/A
Louisville 7-2	N/A	N/A