Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025
Virginia at Louisville
7:30 pm • ESPN2Virginia at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Virginia 9-2 | +7.5 | +6.5-110 | o60-110 | +195 |
 Louisville 7-3 | u59.5 | -6.5-115 | u60-110 | -245 |
L&N Federal Credit Union StadiumLouisville
Virginia vs. Louisville Expert Picks
Mjaybrod
Last 30d: 132-119-0 (+18.1u)
LOU +220 (Live)
0.5u
Fuck!
Collin Wilson
Last 30d: 92-76-0 (+10.9u)
Over 58.5-133
0.67u
Alternate Number at DK
Cam Is Money
Last 30d: 116-105-2 (+9.5u)
LOU o33.5 Team Total-125
1u
Allan Lem
Last 30d: 164-127-3 (+10.1u)
LOU -6.5-110
0.55u
Tailing @Bet_Labs
Sean Zerillo
Last 30d: 53-86-0 (-3.2u)
LOU -6.5-105
0.26u
Bet Labs
Last 30d: 25-26-0 (+3.3u)
LOU -6.5-115
1.73u
Ryan Sura
Last 30d: 61-78-0 (-21.2u)
LOU -6.5-115
1.15u
Brian Bitler
Last 30d: 96-90-2 (+5.4u)
LOU -6.5-110
3u
Vegas Refund
Last 30d: 40-42-1 (-6.5u)
LOU -6.5-110
1.1u
💰🦡 Jake
Last 30d: 101-115-8 (-2.1u)
LOU -6.5-110
1.1u
Mjaybrod
Last 30d: 132-119-0 (+18.1u)
LOU -6.5-110
1u
Red birds take a dookie
Brandon Kravitz
Last 30d: 83-93-2 (-4.8u)
LOU -6.5-115
0.58u
Fading VA after the win of their season.
Boomer Betz
Last 30d: 219-213-10 (-3.8u)
Under 63-110
0.91u
Duck
Last 30d: 148-112-2 (+21.6u)
UVA +7.5-115
1u
Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.
Babs .
Last 30d: 104-110-1 (-9.2u)
LOU -7-110
1u
Boomer Betz
Last 30d: 219-213-10 (-3.8u)
LOU -5.5-110
1u
POD
Virginia vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Virginia vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 4-1 in their last 5 games.
- Louisville are 1-4 in their last 5 games against the spread
- Louisville are 3-0 in their road games against the spread
- The totals have gone OVER in 3 of Louisville' last 5 games
- The totals have gone OVER in 4 of Louisville' 7 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 3-7 | 0-7 | 3-0 | 2-7 | 1-0 |
| 7-4 | 4-2 | 3-2 | 4-3 | 3-1 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 5-5 | 4-3 | 1-2 | 5-4 | 0-1 |
| 5-6 | 4-2 | 1-4 | 3-4 | 2-2 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 7-3 | N/A | N/A | 6-3 | 1-0 |
| 9-2 | N/A | N/A | 6-1 | 3-1 |
Last 5 Matchups
Team Stats
237
Total Yards
383
63
Total Plays
75
3.761904761904762
Yards Per Play
5.1066666666666665
149
YDS
329
19/31
Comps/Atts
34/48
4.806451612903226
YPA
6.854166666666667
1/0
TDs/INTs
2/1
2/20
Sacks/Yards
5/46
7/68
Penalties/Yards
5/60
Virginia vs. Louisville Odds Comparison
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Virginia at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
Virginia 9-2 | o26.5-121 | u26.5-109 |
Louisville 7-3 | o33.5-127 | u33.5-103 |