Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025
Virginia at Louisville
7:30 pm • ESPN2Virginia at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Virginia 3-2 | +7.5 | +6.5-110 | o60-110 | +195 |
Louisville 2-3 | u59.5 | -6.5-115 | u60-110 | -245 |

L&N Federal Credit Union StadiumLouisville
Virginia vs. Louisville Expert Picks
Mjaybrod
Last 30d: 62-78-1 (-14.3u)
LOU +220 (Live)
0.5u
Fuck!
Tyler Shoemaker
Last 30d: 89-123-2 (-29.6u)
LOU -5.5+114
4.39u
LOU -6.5-110
5.5u
Collin Wilson
Last 30d: 86-64-1 (+12.8u)
Over 58.5-133
0.67u
Alternate Number at DK
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
LOU o33.5 Team Total-125
1u
Allan Lem
Last 30d: 44-33-1 (+2.4u)
LOU -6.5-110
0.55u
Tailing @Bet_Labs

Sean Zerillo
Last 30d: 87-108-3 (-6.9u)
LOU -6.5-105
0.26u
Bet Labs
Last 30d: 8-12-1 (-5.5u)
LOU -6.5-115
1.73u
Brian Bitler
Last 30d: 69-78-4 (-21.3u)
LOU -6.5-110
3u
Vegas Refund
Last 30d: 34-34-2 (-3.8u)
LOU -6.5-110
1.1u
💰🦡 Jake
Last 30d: 71-88-0 (-7.0u)
LOU -6.5-110
1.1u
Kody Malstrom
Last 30d: 69-54-2 (+4.3u)
LOU -6.5-106
0.53u
Mjaybrod
Last 30d: 62-78-1 (-14.3u)
LOU -6.5-110
1u
Red birds take a dookie
Doug Ziefel
Last 30d: 369-409-9 (+14.1u)
C.Morris u267.5 Pass Yds-115
0.5u
Brandon Kravitz
Last 30d: 50-61-1 (-3.1u)
LOU -6.5-115
0.58u
Fading VA after the win of their season.
New Owner
Last 30d: 0-0-0 (+0.0u)
Under 63-110
0.91u
Duck
Last 30d: 83-69-1 (-2.6u)
UVA +7.5-115
1u
Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.
Babs .
Last 30d: 64-57-1 (-0.4u)
LOU -7-110
1u
New Owner
Last 30d: 0-0-0 (+0.0u)
LOU -5.5-110
1u
POD
Virginia vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Virginia vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 2-3 in their last 5 games.
- Louisville are 3-2 in their last 5 games against the spread
- Louisville are 0-1 in their road games against the spread
- The totals have gone OVER in 4 of Louisville' last 5 games
- The totals have gone OVER in 2 of Louisville' 3 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 3-2 | 2-1 | 0-1 | 2-2 | 1-0 | |
| 3-2 | 3-0 | 0-1 | 2-2 | N/A |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 4-1 | 2-1 | 1-0 | 3-1 | 1-0 | |
| 2-3 | 1-2 | 0-1 | 1-3 | N/A |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 2-3 | N/A | N/A | 2-2 | 0-1 | |
| 3-2 | N/A | N/A | 2-2 | N/A |
Last 5 Matchups
Team Stats
237
Total Yards
383
63
Total Plays
75
3.761904761904762
Yards Per Play
5.1066666666666665
149
YDS
329
19/31
Comps/Atts
34/48
4.806451612903226
YPA
6.854166666666667
1/0
TDs/INTs
2/1
2/20
Sacks/Yards
5/46
7/68
Penalties/Yards
5/60
Virginia vs. Louisville Odds Comparison
Could not load odds
Virginia at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
Virginia 3-2 | N/A | N/A |
Louisville 2-3 | N/A | N/A |






