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Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025

Virginia at Louisville

7:30 pm • ESPN2

Virginia Cavaliers

4-1
@

Louisville Cardinals

4-0

Virginia at Louisville Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Virginia
4-1
+7.5
+6.5-108
o61.5-110
+195
Louisville
4-0
u59.5
-6.5-112
u61.5-110
-235
location pinSaturday 7:30 p.m.
October 04, 2025
L&N Federal Credit Union StadiumLouisville
thermometer image81°Fahrenheit
rain image0%Rain
wind image3Wind
Virginia vs. Louisville Expert Picks
Brandon Kravitz
Brandon Kravitz
Last 30d: 45-54-0 (-5.4u)
LOU -6.5-115
0.58u
Fading VA after the win of their season.
Boomer Betz
Boomer Betz
Last 30d: 123-106-2 (+20.6u)
Under 63-110
1u
Duck
Duck
Last 30d: 76-61-0 (+8.0u)
UVA +7.5-115
1.15u
Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.
Babs .
Babs .
Last 30d: 76-70-1 (+6.3u)
LOU -7-110
1u
Boomer Betz
Boomer Betz
Last 30d: 123-106-2 (+20.6u)
LOU -5.5-110
1u
POD

Virginia vs. Louisville Previews & Analysis

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    Can We Stay Hot? Our Group Of 5 College Football Picks For Week 6!

    Joshua Nunn•
    Oct 1, 2025 UTC
  • NCAAF Betting Primer: What to Know for Week 6 article feature image

    NCAAF Betting Primer: What to Know for Week 6

    Road ToCFB•
    Sep 30, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Virginia vs. Louisville Public Betting Percentages

Away Logo

Virginia

Public

Home Logo

Louisville

41%

Bets%

59%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Louisville are 4-0 in their last 5 games.
  • Louisville are 1-3 in their last 5 games against the spread
  • Louisville are 1-0 in their road games against the spread
  • The totals have gone OVER in 3 of Louisville' last 4 games
  • The totals have gone OVER in 2 of Louisville' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Louisville		1-30-31-01-3N/A
Virginia		4-14-00-13-01-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Louisville		3-12-11-03-1N/A
Virginia		5-04-01-03-02-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Louisville		4-0N/AN/A4-0N/A
Virginia		4-1N/AN/A3-01-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 27th@PITTW 34-27-6.5 WO 53.5LOU -155
Sep 20thBGSUW 40-17-26.5 LO 50.5LOU -4000
Sep 5thJMUW 28-14-15.5 LU 56.5LOU -690
Aug 30thEKUW 51-17-38.5 LO 56.5LOU -4875
Dec 31st@WASHW 35-34+1 WO 50.5LOU -102
Team Stats

Passing

1481
YDS
1116
125/182
Comps/Atts
95/144
8.14
YPA
7.75
11/5
TDs/INTs
6/4
3/14
Sacks/Yards
8/63

Rushing

1217
Rush Yards
521
217
Attempts
123
5.61
YPC
4.24
17
TDs
9

Turnovers

Fumbles Lost
5
Interceptions
4

Efficiency

26/31 83.9%
Redzone
13/14 92.9%
45/79 0%
3rd Down
24/53 0%
7/12 0%
4th Down
1/2 0%

First Downs

133
Total
83
66
Pass
46
61
Rush
29
6
Penalty
8

Misc

/
Penalties/Yards
/

Virginia vs. Louisville Odds Comparison

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Virginia at Louisville Team Totals

MatchupOverUnder
Virginia
4-1
N/A
N/A
Louisville
4-0
N/A
N/A