SMU vs. Louisville Odds & Betting Predictions - September 19, 2026
SMU at Louisville
7:30 pm • ESPN2SMU at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
SMU 6-1 | +1.5 | +3-105 | o57.5-110 | +122 |
Louisville 4-3 | u56.5 | -3-110 | u57.5-108 | -145 |

L&N Federal Credit Union StadiumLouisville
SMU vs. Louisville Expert Picks
Vegas Refund
Last 30d: 26-38-1 (-16.0u)
LOU -120
1u
Collin Wilson
Last 30d: 77-66-2 (+2.1u)
LOU -118
1u
From the Podcast
Mike McNamara
Last 30d: 68-56-2 (+3.8u)
LOU -120
0.33u
Tyler Shoemaker
Last 30d: 3-4-0 (-0.4u)
SMU +2.5-114
1.14u
SMU +7.5 (Live)-110
1.1u
SMU +101
0.5u
Doug Ziefel
Last 30d: 412-379-11 (+39.2u)
LOU -112
0.5u
K.Brown Anytime TD Scorer Yes+145
0.49u
Ryan Minion
Last 30d: 228-232-2 (+4.0u)
LOU -115
$1.00
#ACTION ✍️✍️ https://discord.gg/aXgTWeNHe
LOU -115
$1.00
Collin Whitchurch
Last 30d: 117-178-4 (-0.9u)
LOU -118
0.5u
The Degenerates
Last 30d: 62-59-1 (-1.8u)
LOU PK-120
1u
Mike Calabrese
Last 30d: 37-58-0 (-6.9u)
LOU -104 (Live)
1u
Adding to my position
LOU -1-110
1u
Always up to fade SMU on the road. 2-5 ATS dating back to the start of 2025 away from Dallas. Lincoln Kienholz isn’t getting enough hype.
Brian Bitler
Last 30d: 72-75-4 (-3.3u)
SMU +1.5-105
3u
Big Bets On Campus (CFB)
Last 30d: 45-52-2 (-8.0u)
RoyalsProps
Last 30d: 39-51-2 (-18.5u)
SMU +2.5-112
1.12u
Player Prop Savant
Last 30d: 86-66-0 (+17.7u)
Under 72.5 (Live)+100
1u
Under 72.5 (Live)-112
1u
Topper
Last 30d: 116-102-4 (+10.1u)
LOU -2.5-105
0.95u
Ranked Contrarian
Overall: 178-118-4,60% (ROI:16%)
Season:0-1-0,0% (ROI:-100%)
#TSA
Mjaybrod
Last 30d: 65-71-0 (-9.4u)
SMU +2-107
1u
Jennings on my dih
Adam Kaufman
Last 30d: 348-316-17 (-12.1u)
LOU -118
1u
💰🦡 Jake
Last 30d: 94-108-1 (+14.1u)
Under 58.5-108
2.16u
Nick Griffith
Last 30d: 56-51-0 (+9.2u)
SMU +110
1u
BBOC Live!
Last 30d: 32-28-2 (+5.1u)
LOU -1.5-110
0.91u
@Breese Best Bets 1 https://www.youtube.com/live/v1vjmEJJqoE?is=dsw7LfpseGfrNr80
SMU vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
SMU vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 2-3 in their last 5 games.
- Louisville are 2-3 in their last 5 games against the spread
- Louisville are 0-2 in their road games against the spread
- The totals have gone OVER in 4 of Louisville' last 5 games
- The totals have gone OVER in 3 of Louisville' 4 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-3 | 3-1 | 0-2 | 3-3 | 1-0 | |
| 3-3-1 | 3-2 | 0-1-1 | 3-2-1 | 0-1 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 6-1 | 3-1 | 2-0 | 5-1 | 1-0 | |
| 3-4 | 2-3 | 1-1 | 2-4 | 1-0 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-3 | N/A | N/A | 4-2 | 0-1 | |
| 6-1 | N/A | N/A | 6-0 | 0-1 |
Last 5 Matchups
Team Stats
222
YDS
177
24/35
Comps/Atts
14/23
6.3428571428571425
YPA
7.695652173913044
1/2
TDs/INTs
2/0
2/2
Sacks/Yards
0/0
8/82
Penalties/Yards
11/110
SMU vs. Louisville Odds Comparison
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SMU at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
SMU 6-1 | N/A | N/A |
Louisville 4-3 | N/A | N/A |






