Wake Forest vs. Louisville Odds & Betting Predictions - September 26, 2026
Wake Forest at Louisville
4:00 pm • ESPNWake Forest at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Wake Forest 8-1 | +13.5 | +11.5-110 | o57.5-110 | +350 |
 Louisville 6-3 | u58.5 | -11.5-110 | u57.5-110 | -450 |
L&N Federal Credit Union StadiumLouisville
Wake Forest vs. Louisville Expert Picks
Collin Wilson
Last 30d: 100-74-2 (+12.4u)
WF +13.5-108
1.02u
Project Louisville -12; Wake pass first offense into a Louisville D that’s 122nd D Pass Success Rate. Finishing drives and penalty advantage for Wake. Cardinals D 120th in opponent pass EPA
LOU -13.5-112
2.24u
Buying out of Wake; 1 full unit on a Louisville. Gio Lopez listed as Questionable, worse condition for Hip after Purdue and Miami game. Handful of DBs could miss for Ville but rushing attack should dominate for Cards
Stuck 🚨
Last 30d: 59-67-1 (+0.7u)
WF +13-108
0.37u
Mike McNamara
Last 30d: 88-76-1 (+7.7u)
WF +12.5-110
0.25u
Sean Zerillo
Last 30d: 162-155-5 (+2.3u)
WF +11.5-105
0.25u
Doug Ziefel
Last 30d: 424-363-11 (+39.8u)
Under 58.5-105
0.5u
WF +13.5-112
0.5u
Jeremiah Rose
Last 30d: 61-55-2 (+7.1u)
WF +13.5-120
0.33u
Collin Whitchurch
Last 30d: 143-202-3 (+4.1u)
WF +13-110
0.5u
The Degenerates
Last 30d: 84-76-1 (+0.4u)
WF +13.5-112
1u
Dan Gaspar
Last 30d: 68-47-10 (+15.9u)
D.Lawrence o38.5 Rush Yds-114
1u
L.Kienholz u252.5 Pass Yds-115
1.15u
Big Bets On Campus (CFB)
Last 30d: 50-57-4 (-8.5u)
JMann
Last 30d: 8-5-0 (+2.3u)
LOU -11.5-110
1u
Gio Lopez is banged up. If he can’t utilize his legs then the O gets stagnant.
Topper
Last 30d: 107-101-1 (-28.0u)
LOU -11.5-112
1u
The Right Favorite
Overall: 742-558-22,57% (ROI:10%)
Season:1-4-0,20% (ROI:-62%)
#TSA
Adam Kaufman
Last 30d: 371-332-18 (-8.8u)
WF +11.5 (Live)-118
0.75u
LOU -11-110
0.83u
💰🦡 Jake
Last 30d: 97-110-1 (+20.1u)
WF +12.5-107
2u
Alex Hinton
Last 30d: 114-125-0 (+8.8u)
Over 57.5-110
1u
Wake Forest vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Wake Forest vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 2-3 in their last 5 games.
- Louisville are 3-2 in their last 5 games against the spread
- Louisville are 1-2 in their road games against the spread
- The totals have gone OVER in 4 of Louisville' last 5 games
- The totals have gone OVER in 4 of Louisville' 5 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 6-3 | 4-1 | 1-2 | 5-3 | 1-0 |
| 7-2 | 4-1 | 3-1 | 4-2 | 2-0 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 7-2 | 4-1 | 2-1 | 6-2 | 1-0 |
| 5-4 | 4-1 | 1-3 | 4-2 | 0-2 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 6-3 | N/A | N/A | 6-2 | 0-1 |
| 8-1 | N/A | N/A | 6-0 | 1-1 |
Last 5 Matchups
Team Stats
402
Total Yards
399
61
Total Plays
74
6.590163934426229
Yards Per Play
5.391891891891892
225
YDS
324
12/19
Comps/Atts
27/36
11.842105263157896
YPA
9
1/0
TDs/INTs
1/1
3/15
Sacks/Yards
4/33
10/85
Penalties/Yards
9/90
Wake Forest vs. Louisville Odds Comparison
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Wake Forest at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
Wake Forest 8-1 | N/A | N/A |
Louisville 6-3 | N/A | N/A |